Protein Info for SO4634 in Shewanella oneidensis MR-1

Name: envZ
Annotation: osmolarity sensor protein EnvZ (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 160 to 179 (20 residues), see Phobius details PF00672: HAMP" amino acids 177 to 228 (52 residues), 49.1 bits, see alignment 8.7e-17 PF00512: HisKA" amino acids 234 to 292 (59 residues), 39.8 bits, see alignment E=5.9e-14 PF02518: HATPase_c" amino acids 335 to 437 (103 residues), 88.5 bits, see alignment E=6.1e-29

Best Hits

KEGG orthology group: K07638, two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC: 2.7.13.3] (inferred from 100% identity to son:SO_4634)

Predicted SEED Role

"Osmolarity sensory histidine kinase EnvZ"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8E8M9 at UniProt or InterPro

Protein Sequence (438 amino acids)

>SO4634 osmolarity sensor protein EnvZ (NCBI ptt file) (Shewanella oneidensis MR-1)
MKLKWWQRLLPRSAFSQTVLLIGCLLLINQLVSYVTVAVYVLKPSYQQINQLIARQINLL
FVDGIDIGREHLTIVDALNAKVRDDGMKVYNQQQAREAGIEQATYYGFWSSQMTEYLGGD
AEVRVTHGRVLQVWIRPPQAPSVWIKVPLIGQNVSDLSPLTLYLMVIGALSVAGGWWFAR
QQNRPLRRLQKAAISVSRGEFPDPLPLKGSSELVEVTNAFNQMAHSMKQLEQDRALLMAG
ISHDLRTPLTRIRLASEMMVEDDQYLKDGIVNDIEDMDAIISQFIAYIRQDQEASREPGQ
INKLIQDIAQAEANRDGEIELALADCPEALFQGLAIKRVLSNLVENAFRYGSGWVRISSQ
FDGKRIGFSVEDNGPGIDESQIPTLFQPFTQGDIARGSVGSGLGLAIIKRIIDRHQGQIT
LSNRAAGGLKAQVWLPRE