Protein Info for SO4598 in Shewanella oneidensis MR-1

Annotation: heavy metal efflux pump, CzcA family (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1045 transmembrane" amino acids 12 to 29 (18 residues), see Phobius details amino acids 339 to 359 (21 residues), see Phobius details amino acids 365 to 384 (20 residues), see Phobius details amino acids 391 to 412 (22 residues), see Phobius details amino acids 446 to 466 (21 residues), see Phobius details amino acids 484 to 505 (22 residues), see Phobius details amino acids 528 to 553 (26 residues), see Phobius details amino acids 875 to 892 (18 residues), see Phobius details amino acids 899 to 918 (20 residues), see Phobius details amino acids 924 to 948 (25 residues), see Phobius details amino acids 983 to 1001 (19 residues), see Phobius details amino acids 1013 to 1036 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1042 (1042 residues), 1215.8 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1036 (1032 residues), 777 bits, see alignment E=1.4e-237

Best Hits

Swiss-Prot: 55% identical to SILA_SALTM: Putative cation efflux system protein SilA (silA) from Salmonella typhimurium

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 58% identity to adn:Alide_2726)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8E8R3 at UniProt or InterPro

Protein Sequence (1045 amino acids)

>SO4598 heavy metal efflux pump, CzcA family (NCBI ptt file) (Shewanella oneidensis MR-1)
MLKYIIEASIRQRLMVLIIAMMITLWGVQELRKTPLDALPDLSDVQVIIKTTYPGQAPKL
VEEQVTYPLSTAMLAVPGAKTVRGFSMFGDSYVYVIFDDGTDIYWARSRVLEYLSQIGSR
LPAGVQPSLGPDASGVGWVFEYALVDRSGNLDLSQLKSLQDWYLKLELQSVAGVSEVATV
GGMEQTYQVVLEPDKMAIYKLDIASIKDAIEKSNSEAGGSVVEMAEAEYMVRAKGYRQTL
EDFREIPLGIASPSGTSLTLKDVATIRKGPAARRGIAELDGEGEVVGGIIVMRYGENALS
TIDAVKAKLEELSAGLPEGVEIVPTYDRSNLILKSVDNLFNKVVEEMLVVGLVCLLFLLH
ARSTLVAIVTLPLSILIAFIVMNKLGVNANIMSLGGIAIAIGAVVDGAIVMIENLHKHLE
QFHSEHQREPNVKEHWRIVTQASTEVGPALFFSLLIITLSFVPVFALEAQEGRLFAPLAY
TKSFAMAASAILAITLVPVLMGYFIRGKIPSENKNPISRVLIALYKPALNLVLNFPKITI
ALALLALVSAWYPFTRMGSEFMPELEEGDLLYMPTALPGISASKAAEVLQQTDRLIKTVP
EVARVFGKVGRAETATDPAPLTMLETTIMLKPHEEWREGMTLDGIINQLQQTVKVPGLTN
AWVQPIKTRIDMLSTGIKTPVGIKITGADVNELQQLGTQIEAILSRMPHTKSAYAERTSG
GRYIDITPKLDVAARYGMNLQDIQDVVRYAIGGMDIGQSVQGAERYPINLRYPRELRDNI
EKLRELPVITKSGNYLPLRNLAEIEITEGAPMLASENGRLISWVFIEIEGTSIGEYITSA
KQTLSAELNVPPRYSYSFAGQYEYMQRVDAKLKQVIPMALGVIFILLMLTFGSTMQASMI
MLSLPFALVGSTWLLYLLDYNISVAVAVGMIALAGVAAEFGVIMLVYLNNAIKHRQDNNT
YHSVEDLKEALIEGAVMRIRPKAMTVATIFFGLLPIMWGAGSGNDVMQKIAAPMVGGMVT
APILSLFVLPALYLLVYSRKLKQVA