Protein Info for SO4326 in Shewanella oneidensis MR-1

Annotation: transcriptional regulator, TetR family (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 202 PF00440: TetR_N" amino acids 22 to 66 (45 residues), 51 bits, see alignment 1.5e-17 PF16295: TetR_C_10" amino acids 71 to 200 (130 residues), 39 bits, see alignment E=1.4e-13 PF22604: TetR_HI_0893_C" amino acids 90 to 198 (109 residues), 88.9 bits, see alignment E=4.7e-29

Best Hits

KEGG orthology group: None (inferred from 100% identity to son:SO_4326)

Predicted SEED Role

"Transcription regulator of multidrug efflux pump operon, TetR (AcrR) family" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8E9F7 at UniProt or InterPro

Protein Sequence (202 amino acids)

>SO4326 transcriptional regulator, TetR family (NCBI ptt file) (Shewanella oneidensis MR-1)
MNERSFISMSIGNRMDSKRDLILRSAEKIIATEGLHNLSMQKLAVDAGVAAGTIYRYFKD
KEDLIIKLRKDVLQQIASKLLENIDEGSFDEKFRRLWFNIVELGREQSHANLSFAQYSHL
PGVDAPEHQAFEREIFQPLHQLFEQAKGQGVIQPLNNALLFSIAFEPAVAIAKRLRRGHL
QCTEHEIQQACELCLQAISVTL