Protein Info for SO3817 in Shewanella oneidensis MR-1

Name: panE
Annotation: 2-dehydropantoate 2-reductase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 327 TIGR00745: 2-dehydropantoate 2-reductase" amino acids 17 to 321 (305 residues), 225.4 bits, see alignment E=5.1e-71 PF02558: ApbA" amino acids 17 to 174 (158 residues), 104.9 bits, see alignment E=3.1e-34 PF08546: ApbA_C" amino acids 199 to 320 (122 residues), 119.5 bits, see alignment E=1.2e-38

Best Hits

KEGG orthology group: K00077, 2-dehydropantoate 2-reductase [EC: 1.1.1.169] (inferred from 100% identity to son:SO_3817)

Predicted SEED Role

"2-dehydropantoate 2-reductase (EC 1.1.1.169)" in subsystem Coenzyme A Biosynthesis (EC 1.1.1.169)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.169

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EAS5 at UniProt or InterPro

Protein Sequence (327 amino acids)

>SO3817 2-dehydropantoate 2-reductase (NCBI ptt file) (Shewanella oneidensis MR-1)
MPGQSKTAAIAPPASEIAILGAGAVGQLICHQLHSAGLAVGLIARESFASNIEATHWQDL
VFSPLLLNNTNTESVSYRVPKLDIESKSAQQIKLLIVCVKAYQVLDAISPLLDKLSPQCH
ILLLHNGMGPHLTLAPRLNGRGLSLGTTSQGVLRQSCWQVKQTGQGLTQFGHFTGPELPQ
ALRERLLHAIPNSEWVEAIIPSLWQKLAVNAAINPLTALHQCPNGTLAQAQFSKTIATIL
DELVEVAAHDGVELDRQRLEERVYRVIELTAANFSSMHQDVAHHRPTEIDQINGYIGDRA
NAHGLSAATNAQMVQSIKQLSAIPPVQ