Protein Info for SO3759 in Shewanella oneidensis MR-1

Annotation: GGDEF domain protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 324 PF13185: GAF_2" amino acids 26 to 152 (127 residues), 39.7 bits, see alignment E=8.5e-14 PF01590: GAF" amino acids 27 to 158 (132 residues), 65.4 bits, see alignment E=1.2e-21 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 165 to 317 (153 residues), 134.5 bits, see alignment E=1.5e-43 PF00990: GGDEF" amino acids 165 to 318 (154 residues), 137.1 bits, see alignment E=7.2e-44

Best Hits

KEGG orthology group: None (inferred from 100% identity to son:SO_3759)

Predicted SEED Role

"Diguanylate cyclase with GAF sensor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EAY2 at UniProt or InterPro

Protein Sequence (324 amino acids)

>SO3759 GGDEF domain protein (NCBI ptt file) (Shewanella oneidensis MR-1)
MQLPPIPDNELQRLSTLKALNILDTNAEERFDRITRLTRRIFALPICVVTLVDASRQWFK
SCQGLEVTETSRDISFCGHAINHDGIFIVNDAQMDPRFHDNPLVTQSPHIRFYAGYPLTI
RGEYRVGTLCLIGNEPREFSADDIETLTDLGQMVEAELLSISLNTLDPLTMISNRRGFEQ
LAFQSLASCRRTNSQAALVFFDLDFFKELNDSFGHRKGDQVLYDFAHLLMAAFRESDVIA
RLGGDEFVVLLSFVKIDAVHVAIERFQSLLEQYNQQHPQQPTLVSSIGVAHWSPELDINL
EDLLDAADRAMYQDKAEHHLNKPE