Protein Info for SO3441 in Shewanella oneidensis MR-1

Name: pyrG
Annotation: CTP synthase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00337: CTP synthase
  • amino acids 2 to 535 (534 residues), 844.1 bits, E=2e-258
• PF06418: CTP_synth_N
  • amino acids 4 to 266 (263 residues), 413.9 bits, E=4e-128
• PF00117: GATase
  • amino acids 301 to 534 (234 residues), 145.1 bits, E=3.2e-46

Best Hits

Swiss-Prot: 100% identical to PYRG_SHEON: CTP synthase (pyrG) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K01937, CTP synthase [EC: 6.3.4.2] (inferred from 100% identity to son:SO_3441)

MetaCyc: 78% identical to CTP synthetase (Escherichia coli K-12 substr. MG1655)
CTP synthase. [EC: 6.3.4.2]

Predicted SEED Role

"CTP synthase (EC 6.3.4.2)" (EC 6.3.4.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleosides salvage (10/10 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• L-citrulline biosynthesis (7/8 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• L-glutamate and L-glutamine biosynthesis (6/7 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• superpathway of L-citrulline metabolism (9/12 steps found)
• L-glutamine degradation I (1/1 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (1/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (1/4 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.2

Sequence Analysis Tools

See Q8EBQ9 at UniProt or InterPro

Protein Sequence (546 amino acids)

>SO3441 CTP synthase (NCBI ptt file) (Shewanella oneidensis MR-1)
MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEV
FVTEDGAETDLDLGHYERFIRTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHIT
NAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLGVELGRDRTLFMHLTLVPFL
GAAGEVKTKPTQHSVKELRSIGIAPDVLICRGDRAIPANERAKISLFCNVEERAVISLKD
VDSIYKIPALLRSQGLDELVVKRFSLTCREADLSEWENVIYQEANPNGEVVIGMVGKYIE
LPDAYKSVNEALKHAGLKNRVSVTIKYIDSQTVEAKGDEVLQGLDGILVPGGFGERGVEG
KILAAKFARENNLPYFGICLGMQVALIEFARNVAGMADAHSTEFNKATPFPVVGLITEWV
DEEGNVEQRHEASDLGGTMRLGAQLCHLLEGSKAAQAYKGNSCVERHRHRYEVNNKYKER
LEQAGLVFSGLSSDRKLVEMIELKDHPWFVAGQFHPEFTSTPRDGHPLFEGFVAAASAHQ
KRDLKK