Protein Info for SO2771 in Shewanella oneidensis MR-1

Name: garR
Annotation: 2-hydroxy-3-oxopropionate reductase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 signal peptide" amino acids 1 to 14 (14 residues), see Phobius details PF01488: Shikimate_DH" amino acids 2 to 70 (69 residues), 32.7 bits, see alignment E=1.5e-11 PF03446: NAD_binding_2" amino acids 3 to 160 (158 residues), 185.3 bits, see alignment E=1.7e-58 PF03807: F420_oxidored" amino acids 3 to 66 (64 residues), 43.8 bits, see alignment E=6.4e-15 PF14833: NAD_binding_11" amino acids 166 to 283 (118 residues), 123.7 bits, see alignment E=1e-39

Best Hits

Swiss-Prot: 78% identical to Y1503_SHEFN: Uncharacterized oxidoreductase Sfri_1503 (Sfri_1503) from Shewanella frigidimarina (strain NCIMB 400)

KEGG orthology group: K00042, 2-hydroxy-3-oxopropionate reductase [EC: 1.1.1.60] (inferred from 100% identity to son:SO_2771)

MetaCyc: 37% identical to tartronate semialdehyde reductase (Escherichia coli K-12 substr. MG1655)
2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]

Predicted SEED Role

"2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60)" in subsystem Allantoin Utilization or D-galactarate, D-glucarate and D-glycerate catabolism or Photorespiration (oxidative C2 cycle) (EC 1.1.1.60)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.60

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EDH8 at UniProt or InterPro

Protein Sequence (291 amino acids)

>SO2771 2-hydroxy-3-oxopropionate reductase (NCBI ptt file) (Shewanella oneidensis MR-1)
MAKVAFIGLGVMGYPMARHLLNKGHEVTVYNRTFAKAQTWVDTYGGRCCPTPKEAAIGQD
IVFTCVGNDNDLREVVLGDDGVIHGMALGTVLVDHTTASADVARELHKVLGEKGIDFLDA
PVSGGQAGAENGVLTVMVGGEQAVFERVKPVIEAFARCAERLGEVGAGQLTKMVNQICIA
GVVQGLAEALQFARKAGLDGEKVVEVISKGAAQSWQMENRYKTMWAQNYDFGFAVDWMRK
DLGIALEEARRNGSHLPLTALVDQFYSEVQAMGGNRWDTSSLLARFEKNTK