Protein Info for SO2388 in Shewanella oneidensis MR-1

Annotation: beta-lactamase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 401 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF00144: Beta-lactamase" amino acids 48 to 392 (345 residues), 253 bits, see alignment E=2.2e-79

Best Hits

Swiss-Prot: 54% identical to AMPC_LYSLA: Beta-lactamase from Lysobacter lactamgenus

KEGG orthology group: K01467, beta-lactamase [EC: 3.5.2.6] (inferred from 100% identity to son:SO_2388)

MetaCyc: 38% identical to beta-lactamase (Escherichia coli K-12 substr. MG1655)
Beta-lactamase. [EC: 3.5.2.6]

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.6

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EEJ3 at UniProt or InterPro

Protein Sequence (401 amino acids)

>SO2388 beta-lactamase (NCBI ptt file) (Shewanella oneidensis MR-1)
MTISPLNSHTLGSTSLGLILLVAPLMVHATPQNALTASQDTKTIKSIVDSAVNPLMAEYG
IPGAVLGISMNGQQYFFPYGVSSKNTAEKVSKNTLFEIGSISKTFTATLATYAQFEGKLT
LTDKVSQYLPELAGSHFDQINLINLATHTAGDLPMQVPDNVTNNTELISYFKAWQPAYPA
GTHRNYANPSIGLLGVIAAKQLGQGFPEAVEQTLFRQLGMTNSYLMVPTNKMADYAQGYN
KQDQPVRLNPGVLADEAYGIKTTAVDLLRFVETNMQQHSVPARLQRAIDATHTGYFDVGP
MTQEMIWEHYPYPISLDNLLAGHTQDVVFGSMPVKAITPPQSPQQNVWINKTGSTGGFAA
YVAYIPAKKLAMVLLSNKNYPVPPRVTVGYQILTGLEKLPN