Protein Info for SO2359 in Shewanella oneidensis MR-1

Annotation: cation transport ATPase, E1-E2 family (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 transmembrane" amino acids 177 to 200 (24 residues), see Phobius details amino acids 213 to 234 (22 residues), see Phobius details amino acids 247 to 267 (21 residues), see Phobius details amino acids 273 to 291 (19 residues), see Phobius details amino acids 428 to 447 (20 residues), see Phobius details amino acids 453 to 483 (31 residues), see Phobius details amino acids 751 to 768 (18 residues), see Phobius details amino acids 774 to 795 (22 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 5 to 88 (84 residues), 98.8 bits, see alignment E=6.1e-32 PF00403: HMA" amino acids 96 to 156 (61 residues), 47.1 bits, see alignment 6.5e-16 TIGR01511: copper-translocating P-type ATPase" amino acids 229 to 794 (566 residues), 486.1 bits, see alignment E=3.4e-149 TIGR01525: heavy metal translocating P-type ATPase" amino acids 247 to 794 (548 residues), 519 bits, see alignment E=3.9e-159 TIGR01512: cadmium-translocating P-type ATPase" amino acids 274 to 796 (523 residues), 384.9 bits, see alignment E=1.1e-118 TIGR01494: HAD ATPase, P-type, family IC" amino acids 281 to 773 (493 residues), 231.4 bits, see alignment E=3.2e-72 PF00122: E1-E2_ATPase" amino acids 309 to 481 (173 residues), 174.6 bits, see alignment E=3.7e-55 PF00702: Hydrolase" amino acids 502 to 706 (205 residues), 89.9 bits, see alignment E=7.5e-29 PF08282: Hydrolase_3" amino acids 686 to 726 (41 residues), 27.2 bits, see alignment 8e-10

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to son:SO_2359)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EEM0 at UniProt or InterPro

Protein Sequence (799 amino acids)

>SO2359 cation transport ATPase, E1-E2 family (NCBI ptt file) (Shewanella oneidensis MR-1)
MTHPSCFHCNEPVLTGTQFVTQINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGNK
QTALVPEALNQFSAYDLPEVQQDFVHSEDNSDSVSLSIDGITCAACAWLIEHKVKQLSGV
RQVMVNSTTQRAMISWDKQQVKLSDILGQISRIGYQAAPYQVDEQELTTKQNSRKFLLRL
GLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSAIRTL
LSGKLNMDVSVSIAIGGAFTASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKAS
VSSSNLHKLVPLTAHLVNEQGQEEIPAKKLRLGDIILVKPGEMVAADGCVVEGHSSINEA
MLTGEQMPIDKPVDSQVFAGTINLEQPIKVKVTALGQDQLVAEIIRLQELASNTKPAVAM
LADKLSRYFSGTILTIATITYFVWLQISPEDAFWVTLSVLVATCPCALALATPTAVTCAT
AIFTRLGIITRKAGVFEKLPQIKHVIFDKTGTLTCGTLSVSEVKCHSHLAIEEVLAIAAA
LETGSLHPIATAFAAYLTPDVVANQVHHEVGFGVKGLINGTEYRIGNAQFTGALVNPEFI
NQQIWLAWGNDDSLEVLATIEIKDNIRVDSKETVGILKQQGCRVSIASGDSSGHVHQLAK
ALGITDVHSGLTPADKLALVKKLQQSNPVVMFGDGINDAPVLAGADLSVAMGSGSAIAKN
SADLILLGDHLSRFTQAVRVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAAIGM
SASSLIVVGNSLRLLRIKI