Protein Info for SO2195 in Shewanella oneidensis MR-1

Annotation: inter-alpha-trypsin inhibitor domain protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 760 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 727 to 744 (18 residues), see Phobius details PF13757: VIT_2" amino acids 87 to 149 (63 residues), 27.4 bits, see alignment E=6.4e-10 TIGR03788: marine proteobacterial sortase target protein" amino acids 87 to 746 (660 residues), 885.6 bits, see alignment E=1.8e-270 PF08487: VIT" amino acids 88 to 196 (109 residues), 107.9 bits, see alignment E=8.3e-35 PF13768: VWA_3" amino acids 379 to 535 (157 residues), 80.3 bits, see alignment E=4.2e-26 PF00092: VWA" amino acids 380 to 545 (166 residues), 47.2 bits, see alignment E=7.7e-16 PF13519: VWA_2" amino acids 380 to 489 (110 residues), 47.1 bits, see alignment E=8.1e-16

Best Hits

KEGG orthology group: K07114, uncharacterized protein (inferred from 100% identity to son:SO_2195)

Predicted SEED Role

"Inter-alpha-trypsin inhibitor domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EF10 at UniProt or InterPro

Protein Sequence (760 amino acids)

>SO2195 inter-alpha-trypsin inhibitor domain protein (NCBI ptt file) (Shewanella oneidensis MR-1)
MITKNRVKEVCEALAMLIISASICWFIPFAVLASPNSVGALSEPQNITAVFDEHTASRLP
TFSYDDVTQGMLVYQTANGNLMPSLPVDTQVSMRVSGLTNRVSVKQVFSNHTGFVLNGRY
LFPLPNEAAVDSLRLHIGERVIEGQIHPKQAAQQIFEQAKAEGKRASLVSQERPNMFTTE
VANLAPNEKLVVEISYQETIKYDDGVFSLRFPLVVAPRYIPGLTLGGESGQTGRVTSSQV
FDADRIIAPIRGAPGEEDPVLKADIKVNLGLGVDKAAILSPYHAITLDEQQGGLTASLAN
RVRAERDFVLQWRLEQGVSPVAWVFNQNGKTHQTQAASDDGSMVNTAASTSASNIDNYSL
VMVLPPKVEASGQLNLPRELILVIDTSGSMAGDSIIQAKNALRYALRGLKAQDSFNIIEF
NSDVSLLSPVPLPATAENLAIARQFVNRLQADGGTEMSLALEAALPKQRPSRAASENNVL
QQVIFMTDGSVGNEEALFELIRHQIGDNRLFTVGIGSAPNSHFMQRAAELGRGTFTYIGD
VDEVEQKINQLLTKIQYPVLTDLQVRFDDGTVPDYWPSPIPDLYRGEPVLISIKHQPREP
KELVISGRQGHKNWQQFVSLESTELNNAAAAVEQQVAGLDLLWARKQIAALELSKNGAND
DKVKQQVTALSMNYHLVSPYTSLVAVNLTPITTNAMSRDAVVRQHLPLGWQPFGVLPQTS
TSSRFDMLLGGVVLMIALMLALFIRRQQRQQHLMMQALSH