Protein Info for SO2193 in Shewanella oneidensis MR-1

Annotation: DNA-binding response regulator (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 230 TIGR03787: proteobacterial dedicated sortase system response regulator" amino acids 2 to 228 (227 residues), 426.9 bits, see alignment E=8.6e-133 PF00072: Response_reg" amino acids 4 to 115 (112 residues), 80.2 bits, see alignment E=1.3e-26

Best Hits

Swiss-Prot: 32% identical to YVCP_BACSU: Uncharacterized transcriptional regulatory protein YvcP (yvcP) from Bacillus subtilis (strain 168)

KEGG orthology group: K02483, two-component system, OmpR family, response regulator (inferred from 100% identity to son:SO_2193)

Predicted SEED Role

"DNA-binding response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EF12 at UniProt or InterPro

Protein Sequence (230 amino acids)

>SO2193 DNA-binding response regulator (NCBI ptt file) (Shewanella oneidensis MR-1)
MKRIAIVEDEAAIRENYKDVLQQHGYSVQTYADRPSAMLAFNTRLPDLAIIDIGLGNEID
GGFMLCQSLRAMSNTLPIIFLTARDSDFDTVCGLRLGADDYLSKEVSFPHLTARLAALFR
RSELAASQTPQENLLERGPLTIDANRMQVYWNQIAIELTVTEFWMVHALAKHPGHVRSRH
ELMQEAKIFVDDSTITSHVKRIRKKFMAAAPEFDCIDTVYGMGYRWDSLA