Protein Info for SO2017 in Shewanella oneidensis MR-1

Annotation: hypothetical thioredoxin-like protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 287 PF00085: Thioredoxin" amino acids 5 to 104 (100 residues), 37.3 bits, see alignment E=3.5e-13 PF14559: TPR_19" amino acids 129 to 193 (65 residues), 49.9 bits, see alignment E=4.8e-17 PF14561: TPR_20" amino acids 199 to 287 (89 residues), 94.4 bits, see alignment E=6.4e-31

Best Hits

Swiss-Prot: 42% identical to CNOX_ECOLI: Chaperedoxin (cnoX) from Escherichia coli (strain K12)

KEGG orthology group: K05838, putative thioredoxin (inferred from 100% identity to son:SO_2017)

Predicted SEED Role

"FIG000875: Thioredoxin domain-containing protein EC-YbbN"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EFF6 at UniProt or InterPro

Protein Sequence (287 amino acids)

>SO2017 hypothetical thioredoxin-like protein (NCBI ptt file) (Shewanella oneidensis MR-1)
MDNILDLTKDNIQQVVDASMQQLVVMVFWAQPQPQSVAMVQTLEQLATQHAGRFVLAKVN
CEAELEIANYFRIQALPTTLVLDKGQPIDGFAGLQEAVQVSAMLEKHLPPLWQLQLEQAK
ALLALTQVSAEDLTTAAVLLKDAYSASNHAAEVSLVLADVYLMQGELAQAQGLLEQIGLA
DQDGYYQSLRAKLTLALDAADTPEIRELQQKFEQNPHDLVLLLELCKALHSAHRDEEALT
HLYGVLSKDLSAENGKVKQTFMEILTALGQGNSLANQYRRKLYTLLY