Protein Info for SO1857 in Shewanella oneidensis MR-1

Annotation: hypothetical ATP-dependent protease (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 577 PF13654: AAA_32" amino acids 107 to 220 (114 residues), 40.1 bits, see alignment E=5.5e-14 PF20436: LonB_AAA-LID" amino acids 250 to 309 (60 residues), 33.3 bits, see alignment 6.2e-12 PF05362: Lon_C" amino acids 419 to 525 (107 residues), 31.6 bits, see alignment E=1.9e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to son:SO_1857)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EFV8 at UniProt or InterPro

Protein Sequence (577 amino acids)

>SO1857 hypothetical ATP-dependent protease (NCBI ptt file) (Shewanella oneidensis MR-1)
MNSLLIPSSSLAPEFNLPVLPQLPTGFKALLLGQERVLDAFKLHNAIADQQLYLADFPGI
DRQLMMKALMETLEPLPAAYLVAKRPEDNAIQFHWQYEAPQDNQGSIAEKHVSYRYLSGN
IRRSDLLGRMVQSGNSSKYQAGALAECHYVFICAESLWKREGLWDLLMQILTQKEYQISH
NLSPIPLNCKIILIGAGLIYSQIRSEDWQFQRHFNLLAELAGELDLTRFKEAQYASWLQT
VAQNVDATLEQSSLAPLFRHSARLTEHQRRLSLSMLDLAQLMAQAKVYRGKSTINAASIE
RALSQANYRHNSSEEFSGQSFDDNFINLPTEGAMVGQINGLTVIDAIDHCYGEPARITAT
VHYGDGEVADIERKSELGGNIHAKGMMILSACLYRIFGRDAPLHLNANIVFEQSYQEIDG
DSASLAEYCCLMSAIAEQPIIQSLAITGALDQFGNVQAIGGINEKIEGFFNLCERRGLTG
KQGVIMPKSNMLQLNLHSKVITAVGKGLFHIYAIEHMDEAVELLMQMPAGVADEDNDFPA
ESLYGLVQQRLDKLAGNGEEEIGLITRLLAKLGFFRH