Protein Info for SO1689 in Shewanella oneidensis MR-1

Annotation: cation transport ATPase, E1-E2 family (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 753 transmembrane" amino acids 91 to 108 (18 residues), see Phobius details amino acids 119 to 137 (19 residues), see Phobius details amino acids 158 to 180 (23 residues), see Phobius details amino acids 186 to 205 (20 residues), see Phobius details amino acids 339 to 361 (23 residues), see Phobius details amino acids 367 to 390 (24 residues), see Phobius details amino acids 699 to 718 (20 residues), see Phobius details amino acids 724 to 744 (21 residues), see Phobius details PF00403: HMA" amino acids 6 to 61 (56 residues), 41.5 bits, see alignment 3.5e-14 TIGR01511: copper-translocating P-type ATPase" amino acids 137 to 749 (613 residues), 597.8 bits, see alignment E=4.7e-183 TIGR01525: heavy metal translocating P-type ATPase" amino acids 155 to 748 (594 residues), 610.5 bits, see alignment E=7.2e-187 TIGR01494: HAD ATPase, P-type, family IC" amino acids 194 to 480 (287 residues), 133.5 bits, see alignment E=1.5e-42 amino acids 532 to 717 (186 residues), 162.9 bits, see alignment E=1.8e-51 PF00122: E1-E2_ATPase" amino acids 223 to 403 (181 residues), 177.6 bits, see alignment E=4.6e-56 PF00702: Hydrolase" amino acids 420 to 652 (233 residues), 124.4 bits, see alignment E=1.9e-39 PF12710: HAD" amino acids 548 to 649 (102 residues), 27.7 bits, see alignment E=8.7e-10 PF08282: Hydrolase_3" amino acids 627 to 677 (51 residues), 21.7 bits, see alignment 3.9e-08

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to son:SO_1689)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EGB6 at UniProt or InterPro

Protein Sequence (753 amino acids)

>SO1689 cation transport ATPase, E1-E2 family (NCBI ptt file) (Shewanella oneidensis MR-1)
MSQIKLYVANMNCAGCVAKIEKAFAAESNVSARINLADKQVTVDGKISPDAALAVMDKAG
FPAQLIVDAKAAAEEKRIEDAAEYKLRMRQAVAALAVGIPMMLWGLLGGEMMINSPSMQL
GWGIMGLITLALLIGTGRHFYQGMWRALKAKTTNMDTLIVLGTSTAWLYSMVMVLIPSAF
PMDTRHVYFEASVMILGLINLGHALELKARGKTSEAVQRLLGLQSSRAIRIGENGDEEVE
ISQLKLGDKLRLRPGDRVALDGVVESGQSLLDEAMLTGEPIPVPKQVGDSLSAGTVNGNG
SLVYRVSAGQRDTRLAKIIALVQEAQTSKMPIGRLADNISAVFVPTVVVIALLAAAIWYL
VGPEPALSHALVVLTSVLIIACPCALGLATPMSIMVSVGRAAQMGVLVKNGEALQSASKV
DCVVLDKTGTVTQGKPEVTDIHWHGEYEQALSADDKSALLGAIASLEQHSEHPLANAIVS
YVKQASIPLPATEIFTNHQGKGIEGRVNYTDYLVGNQALMTAFKVPPLTVLANSNETSEL
DATAHFAKQGKTPIYVAEAGKLVATIAIADPIKADAKEAISAIRSQGIRVVLLTGDNPQT
AQAVAEQVGIEEVIAGVLPEQKQQHIKALQQQGHVVAMVGDGINDAPALMSADVGIAMGS
GTEVAIESADMTLLSHQLIVIANLFALSRATMTNIKQNLFGAFIYNSIGIPVAAGVLYPL
TGMLLSPVIAGAAMALSSLTVVTNANRLRQQKL