Protein Info for SO1065 in Shewanella oneidensis MR-1

Name: fkpA
Annotation: FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 255 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF01346: FKBP_N" amino acids 40 to 146 (107 residues), 85.8 bits, see alignment E=3.1e-28 PF00254: FKBP_C" amino acids 153 to 240 (88 residues), 106.1 bits, see alignment E=9.6e-35

Best Hits

Swiss-Prot: 50% identical to FKBA_AERHY: FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (fkpA) from Aeromonas hydrophila

KEGG orthology group: K03772, FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC: 5.2.1.8] (inferred from 100% identity to son:SO_1065)

MetaCyc: 43% identical to peptidyl-prolyl cis-trans isomerase/OMP chaperone FkpA (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"FKBP-type peptidyl-prolyl cis-trans isomerase FkpA precursor (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase or Potassium homeostasis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EHY9 at UniProt or InterPro

Protein Sequence (255 amino acids)

>SO1065 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (NCBI ptt file) (Shewanella oneidensis MR-1)
MKSIYKLSLVALAVIGLSACNQEEKATNASTNVELTTEAQKEAYSVGASIGRYMSGHIKE
QEELGLPVDRTLIVTGFTSGLNDQLKLTEEEMQTILQSLDKKLNDKRQEQAKAIAVKNLE
DGKKFLDENKAKSGVVTTESGLQYEVLTPGSGEKPAAEDTVEVDYVGTLIDGKEFDSSYK
RGESLKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGDRDNGTIPPNSTLIFEVELK
SIEKAAAPAAEPAKK