Protein Info for SO0740 in Shewanella oneidensis MR-1

Annotation: melanin biosynthesis protein TyrA, putative (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 42% identical to YFEX_ECOLI: Dye-decolorizing peroxidase YfeX (yfeX) from Escherichia coli (strain K12)

KEGG orthology group: K07223, putative iron-dependent peroxidase (inferred from 100% identity to son:SO_0740)

MetaCyc: 42% identical to porphyrinogen peroxidase (Escherichia coli K-12 substr. MG1655)
PROTOHEMEFERROCHELAT-RXN [EC: 4.98.1.1]; RXN-11813 [EC: 4.98.1.1, 1.11.1.19]; RXN0-7325 [EC: 4.98.1.1, 1.11.1.19]

Predicted SEED Role

"Predicted dye-decolorizing peroxidase (DyP), YfeX-like subgroup"

MetaCyc Pathways

superpathway of heme b biosynthesis from glutamate (10/10 steps found)
superpathway of heme b biosynthesis from uroporphyrinogen-III (6/6 steps found)
superpathway of heme b biosynthesis from glycine (7/8 steps found)
heme b biosynthesis I (aerobic) (4/4 steps found)
heme b biosynthesis II (oxygen-independent) (4/4 steps found)
heme b biosynthesis V (aerobic) (4/4 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.11.1.19 or 4.98.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EIU4 at UniProt or InterPro

Protein Sequence (311 amino acids)

>SO0740 melanin biosynthesis protein TyrA, putative (NCBI ptt file) (Shewanella oneidensis MR-1)
MDIQNMPREQLGVCAEGNLHSVYLMFNANDNVESQLRPCIANVAQYIYELTDQYSDSAFN
GFVAIGANYWDSLYPESRPEMLKPFPAMQEGNREAPAIEYDLFVHLRCDRYDILHLVANE
ISQMFEDLVELVEEERGFRFMDSRDLTGFVDGTENPKGRHRQEVALVGSEDPEFKGGSYI
HVQKYAHNLSKWHRLPLKKQEDIIGRTKQDNIEYESEDKPLTSHIKRVNLKDENGKSIEI
LRQSMPYGSLKEQGLMFISTCRTPDHFEKMLHSMVFGDGAGNHDHLMHFTSALTGSSFFA
PSLDFLMQFDN