Protein Info for SO0617 in Shewanella oneidensis MR-1

Name: argD
Annotation: acetylornithine aminotransferase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to ARGD_SHEON: Acetylornithine aminotransferase (argD) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K00821, acetylornithine/N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.11 2.6.1.17] (inferred from 100% identity to son:SO_0617)

MetaCyc: 65% identical to succinylornithine transaminase subunit (Pseudomonas aeruginosa)
Succinylornithine transaminase. [EC: 2.6.1.81]; Ornithine aminotransferase. [EC: 2.6.1.81, 2.6.1.13]; Acetylornithine transaminase. [EC: 2.6.1.81, 2.6.1.13, 2.6.1.11]

Predicted SEED Role

"Acetylornithine aminotransferase (EC 2.6.1.11) / N-succinyl-L,L-diaminopimelate aminotransferase (EC 2.6.1.17) / Succinylornithine transaminase (EC 2.6.1.81)" in subsystem Arginine Biosynthesis extended or Lysine Biosynthesis DAP Pathway or Arginine and Ornithine Degradation (EC 2.6.1.11, EC 2.6.1.17, EC 2.6.1.81)

MetaCyc Pathways

aspartate superpathway (23/25 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
L-lysine biosynthesis I (9/9 steps found)
L-arginine biosynthesis II (acetyl cycle) (9/10 steps found)
L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
L-arginine degradation II (AST pathway) (5/5 steps found)
L-ornithine biosynthesis I (5/5 steps found)
L-citrulline biosynthesis (7/8 steps found)
L-ornithine biosynthesis II (3/3 steps found)
L-proline biosynthesis III (from L-ornithine) (3/3 steps found)
superpathway of arginine and polyamine biosynthesis (13/17 steps found)
L-arginine degradation XIII (reductive Stickland reaction) (4/5 steps found)
superpathway of L-citrulline metabolism (9/12 steps found)
L-arginine degradation VI (arginase 2 pathway) (3/4 steps found)
L-N^δ-acetylornithine biosynthesis (5/7 steps found)
L-arginine degradation I (arginase pathway) (2/3 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.11 or 2.6.1.13 or 2.6.1.17 or 2.6.1.81

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P59320 at UniProt or InterPro

Protein Sequence (405 amino acids)

>SO0617 acetylornithine aminotransferase (NCBI ptt file) (Shewanella oneidensis MR-1)
MSVDMKLNRAQFDAVMVPNYAPAAVIPVRGEGSRVWDQEGNEFIDFAGGIAVNCLGHCHP
ALVNALKTQGEKLWHLSNVMTNEPALELATKLVNSTFAERVYFANSGAEANEAALKLARR
YALEKHGVEKDEIIAFDKAFHGRTFFTVSVGGQAAYSDGFGPKPQSITHLPFNDVAALEA
AVSDKTCAIMLEPLQGEGGIIDADPAFLKAVRELANKHNALVIFDEVQTGVGRTGELYAY
MGTDIVPDILTTAKALGGGFPIAAMLTTTEIAEHLKVGTHGSTYGGNPLACAIGNAVLDV
VNTPEVLNGVKHREQLLRDGLNKINEKYHVFSEVRGKGLLLGAVLNEQYQGRSRDFLVAS
VAEGLMSLMAGANVVRFAPSLVIPEADIAEGLARFERAVASIAAA