Protein Info for SO0601 in Shewanella oneidensis MR-1

Name: mutL
Annotation: DNA mismatch repair protein MutL (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 631 TIGR00585: DNA mismatch repair protein MutL" amino acids 2 to 308 (307 residues), 319.4 bits, see alignment E=1.7e-99 PF02518: HATPase_c" amino acids 21 to 77 (57 residues), 33.8 bits, see alignment 7.9e-12 PF13589: HATPase_c_3" amino acids 24 to 121 (98 residues), 55.3 bits, see alignment E=1.5e-18 PF01119: DNA_mis_repair" amino acids 213 to 327 (115 residues), 116.9 bits, see alignment E=8.4e-38 PF08676: MutL_C" amino acids 494 to 585 (92 residues), 41.5 bits, see alignment E=2.3e-14

Best Hits

Swiss-Prot: 100% identical to MUTL_SHEON: DNA mismatch repair protein MutL (mutL) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 100% identity to son:SO_0601)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EJ70 at UniProt or InterPro

Protein Sequence (631 amino acids)

>SO0601 DNA mismatch repair protein MutL (NCBI ptt file) (Shewanella oneidensis MR-1)
MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRIDIEIDKGGSKLIKIRDNG
SGIPKEELALALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQSEA
WQAYAEGVEMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
VRGDIHFTLTHNGKTVRNYRPAMNEPQYLQRLTQVAGRPFADEALRVECQHDDLRLSGYL
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNV
HPAKHEVRFHQSRYVHDYILQALQSALEEAGELRFEPHSPQIDDSSPYVKPETESSAFEL
QSTESNAKYLGIDTTGERQAEARVVEYRSSDMPKMRTGTAVQSNAFGSMSVPRETRSGSS
GESRPRAELPSKTAIASYGALLQTPSYSVQDKAYQPTLPMPSILDGQFWVFTDGPKLSLL
RIESVALATRSDEIETKLATGLIGQPLLMPVSVAADTDWSSLLDEHATLIRQLGLELTIR
YQQLIIKKVPPYLRDCQLARVIPEWLQSLRFEAPAPNALAIWLAEQSLTGFISAPDVWVA
YCQLTEEKRQQIASKAVSLPWQSWLEEQAIE