Protein Info for SO0520 in Shewanella oneidensis MR-1

Annotation: heavy metal efflux pump, CzcA family (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1075 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 355 to 372 (18 residues), see Phobius details amino acids 379 to 398 (20 residues), see Phobius details amino acids 405 to 429 (25 residues), see Phobius details amino acids 484 to 504 (21 residues), see Phobius details amino acids 517 to 543 (27 residues), see Phobius details amino acids 574 to 592 (19 residues), see Phobius details amino acids 909 to 928 (20 residues), see Phobius details amino acids 935 to 958 (24 residues), see Phobius details amino acids 965 to 985 (21 residues), see Phobius details amino acids 1007 to 1026 (20 residues), see Phobius details amino acids 1038 to 1061 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1063 (1058 residues), 848.1 bits, see alignment E=9.1e-259 PF03176: MMPL" amino acids 859 to 1064 (206 residues), 22.5 bits, see alignment E=5.1e-09

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 100% identity to son:SO_0520)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EJE7 at UniProt or InterPro

Protein Sequence (1075 amino acids)

>SO0520 heavy metal efflux pump, CzcA family (NCBI ptt file) (Shewanella oneidensis MR-1)
MLQKAIEAAIKNRLLVVLALLAAVAASVAMLPKLNLDAFPDVTNVQVTINTEAEGLAAEE
VEKLISYPVESAMYALPAVTEVRSLSRTGLSIVTVVFAEGTDIYFARQQVFEQLQAAREM
IPSGVGVPEIGPNTSGLGQIYQYILRADPSAGINAAELRSLNDYLVKLILMPVGGVTDVL
SFGGEVRQYQVQVDPNKLRAYGLSMAQVSEALESNNRNAGGWFMDQGQEQLVVRGYGMLP
AGEAGLASIAQIPLTEVRGTPVRVGDIAKVDFGSEIRVGAVTMTRRDEAGQAQALGEVVA
GVVLKRMGANTKATIDDIDARINLIEQALPKGVSFEVFYDQADLVDKAVATVRDALLMAF
VFIVVILALFLVNIRATLLVLLSIPVSIGLALMVMSYYGLSANLMSLGGLAVAIGMLVDG
SVVMVENIFKHLTQPDRRHLTQARARADGEADPYHGDEDGGVNADDDDHQGNMAVRIMLA
AKEVCSPIFFATAIIIVVFAPLFALEGVEGKLFQPMAVSIILAMISALLVALIAVPALAV
YLFKRGVVLKESVILRPLDNAYRKLLSATLARPKMVVLSAVIMFVMSMALLPRLGTEFVP
ELEEGTINLRVTLAPTASLGTSLDVAPKLEALLLQFPEVEYALSRIGAPELGGDPEPVSN
IEIYIGLKPIEEWQSASSRLALQRLMEEKLSVFPGLLLTFSQPIATRVDELLSGVKAQLA
IKLFGPDLAVLSDKGQVLTDLVAKIPGAVDVSLEQVSGEAQLVVRPDRSQLARYGISVDQ
VMTLVSQGIGGASAGQVIDGNARYDINLRLAAEFRSSPDVIKDLLLSGTNGAIVRLGEVA
SVEVEMAPPNIRRDDVQRRVVVQANVAGRDMGSIVNDIYALVPKADLPAGYTVIVGGQYE
NQQRAQQKLMLVVPVSIALIALLLYFSFGAVKQVLLIMANVPLALIGGIVALFVSGTYLS
VPSSIGFITLFGVAVLNGVVLVDSINQRRQSGESLYDSVYEGTVGRLRPVLMTALTSALG
LIPILVSSGVGSEIQKPLAVVIIGGLFSSTALTLLVLPTLYRWLYRRDKRIDELG