Protein Info for SO0198 in Shewanella oneidensis MR-1

Annotation: transcriptional regulator, TetR family (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 204 PF00440: TetR_N" amino acids 17 to 58 (42 residues), 35.2 bits, see alignment 8.8e-13 PF21943: TetR_C_46" amino acids 87 to 187 (101 residues), 30.6 bits, see alignment E=3.5e-11

Best Hits

Swiss-Prot: 68% identical to FABR_SALCH: HTH-type transcriptional repressor FabR (fabR) from Salmonella choleraesuis (strain SC-B67)

KEGG orthology group: None (inferred from 98% identity to sbl:Sbal_4180)

Predicted SEED Role

"Unsaturated fatty acid biosythesis repressor FabR, TetR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EK97 at UniProt or InterPro

Protein Sequence (204 amino acids)

>SO0198 transcriptional regulator, TetR family (NCBI ptt file) (Shewanella oneidensis MR-1)
MGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELGL
TMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVDTFMEVLDSNPNVFRILLHERSGTSAAF
RAAVAREIEHFISELAHYTEATAGRTPMLARAQAEALVTLVFNAGASALDMKRADRKVLA
DQLVMQLRMVAKGAEALQHKVEHR