Protein Info for Rru_A3767 in Rhodospirillum rubrum S1H

Annotation: Ferric uptake regulator (FUR) family (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 140 PF01475: FUR" amino acids 11 to 130 (120 residues), 133.9 bits, see alignment E=1.6e-43

Best Hits

Swiss-Prot: 69% identical to FUR_RHILV: Ferric uptake regulation protein (fur) from Rhizobium leguminosarum bv. viciae

KEGG orthology group: K03711, Fur family transcriptional regulator, ferric uptake regulator (inferred from 100% identity to rru:Rru_A3767)

Predicted SEED Role

"Ferric uptake regulation protein FUR" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases or Iron acquisition in Vibrio or Oxidative stress or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RMT4 at UniProt or InterPro

Protein Sequence (140 amino acids)

>Rru_A3767 Ferric uptake regulator (FUR) family (NCBI) (Rhodospirillum rubrum S1H)
MMSSIEKRCLEQGMKMTEQRRVIARVLSDAEDHPDVEEVYRRATGIDPRISIATVYRTVR
LFEEAGILERHDFRDGRARYEEVSEDHHDHLINLTTGDVIEFHSDQIEVIQQEIARKLGY
RLIGHRLELYGVPLDDKKKS