Protein Info for Rru_A3642 in Rhodospirillum rubrum S1H

Annotation: Negative regulator of class I heat shock protein (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 352 TIGR00331: heat-inducible transcription repressor HrcA" amino acids 14 to 350 (337 residues), 326.3 bits, see alignment E=1.5e-101 PF01628: HrcA" amino acids 115 to 337 (223 residues), 222.2 bits, see alignment E=4e-70

Best Hits

Swiss-Prot: 56% identical to HRCA_OLICO: Heat-inducible transcription repressor HrcA (hrcA) from Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)

KEGG orthology group: K03705, heat-inducible transcriptional repressor (inferred from 100% identity to rru:Rru_A3642)

Predicted SEED Role

"Heat-inducible transcription repressor HrcA" in subsystem Heat shock dnaK gene cluster extended

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RN59 at UniProt or InterPro

Protein Sequence (352 amino acids)

>Rru_A3642 Negative regulator of class I heat shock protein (NCBI) (Rhodospirillum rubrum S1H)
MVVTGRGGIVTELDERSRQIFGQIVETYVETGEPVGSRTLSRRLTVALSPATIRNVMADL
EDLGLLYAPHTSAGRLPTDAGLRLFVNGLMELGGLTSEERRHIDGRVQAAGKNLDDMLSD
ATSLLSGLARCAGLVLAPKTDSALKHIEFVPLGPGRAMVIMITENGLVENRVLEVPQGLP
PSALAEATNYLNARLTGRTLEEARSEIQEELDSHRSALDDLAQRVVETGMATWSGGTRGG
ELIVRGQSHLLADVTALEDLERIRDLFDTLETKEQVLRILDMVNLAEGVQIFIGAENELF
SVSGCSMIVAPYQNSREEIVGAIGVIGPTRINYRRIIPLVDYTSKVISRMIG