Protein Info for Rru_A3595 in Rhodospirillum rubrum S1H

Annotation: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 241 PF00977: His_biosynth" amino acids 3 to 230 (228 residues), 269.6 bits, see alignment E=2e-84 TIGR00007: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase" amino acids 4 to 234 (231 residues), 260.9 bits, see alignment E=5.2e-82

Best Hits

Swiss-Prot: 100% identical to HIS4_RHORT: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K01814, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC: 5.3.1.16] (inferred from 100% identity to rru:Rru_A3595)

Predicted SEED Role

"Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)" in subsystem Histidine Biosynthesis (EC 5.3.1.16)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RNA6 at UniProt or InterPro

Protein Sequence (241 amino acids)

>Rru_A3595 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (NCBI) (Rhodospirillum rubrum S1H)
MILFPAIDLKDGQCVRLRKGEMDQATVFNDSPADQAAAFALAGCRWIHVVDLNGAFAGRP
VNAPAVEAILAAVDLPVQLGGGIRDLAAIDLWLDKGVRRVILGTVALRDPQLVREACKRH
PGRIAVGIDARGGMVAVEGWAETSAVSALDLALRFEDAGVAAIVHTDIDRDGLLAGPNLD
ATAALAERLTTPVIVSGGVASLDDLRAIRARAAAGLEGVISGRALYDGRIDLAEALAVLA
D