Protein Info for Rru_A3484 in Rhodospirillum rubrum S1H

Annotation: Secretion protein HlyD (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 354 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details PF13533: Biotin_lipoyl_2" amino acids 52 to 96 (45 residues), 39.1 bits, see alignment 1e-13 PF16576: HlyD_D23" amino acids 165 to 291 (127 residues), 50.4 bits, see alignment E=3.7e-17 PF13437: HlyD_3" amino acids 216 to 334 (119 residues), 51.4 bits, see alignment E=3.2e-17

Best Hits

Swiss-Prot: 38% identical to EMRA_ACIBT: Colistin resistance protein EmrA (emrA) from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A3484)

Predicted SEED Role

"Membrane fusion component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RNL7 at UniProt or InterPro

Protein Sequence (354 amino acids)

>Rru_A3484 Secretion protein HlyD (NCBI) (Rhodospirillum rubrum S1H)
MSKVKHFFPAGLALSIGLIGALLVLYAWHLPPFRSAVETTDNAYVRAQVTMISPQSAGYV
TAVTVHDFQTVKAGTPLFQIDDRIYAQKLKQAQATLEMKRAALENSEQSERAAQARIRSS
EAEIASAIAALDVARSTARRTEALLARGVSTQSSADQARSTLAQAEALVHKSQAALDVSR
EDLRSIRVNRDSLQADIANAQAAVELATIDLHNTSIVAPIDGTLGEIGVRLGQYVSAGTQ
LAALVPARRWVIANFKETQLAGIQIGQAVSFRVDALQGTALAGHVEAFSPATGSEFTVLK
SDNATGNFTKVTQRLPVRIAIDPDQAQAALLAPGMSVVVRIDTAPSERDGKHPS