Protein Info for Rru_A3324 in Rhodospirillum rubrum S1H

Annotation: copper-translocating P-type ATPase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 809 transmembrane" amino acids 185 to 207 (23 residues), see Phobius details amino acids 220 to 240 (21 residues), see Phobius details amino acids 252 to 272 (21 residues), see Phobius details amino acids 279 to 298 (20 residues), see Phobius details amino acids 435 to 457 (23 residues), see Phobius details amino acids 464 to 489 (26 residues), see Phobius details amino acids 762 to 778 (17 residues), see Phobius details amino acids 784 to 803 (20 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 18 to 61 (44 residues), 35.3 bits, see alignment 3.1e-12 PF00403: HMA" amino acids 99 to 143 (45 residues), 33.5 bits, see alignment 9e-12 TIGR01511: copper-translocating P-type ATPase" amino acids 237 to 805 (569 residues), 486.7 bits, see alignment E=2.2e-149 TIGR01525: heavy metal translocating P-type ATPase" amino acids 254 to 805 (552 residues), 502.6 bits, see alignment E=3.5e-154 TIGR01512: cadmium-translocating P-type ATPase" amino acids 282 to 806 (525 residues), 329.8 bits, see alignment E=5.9e-102 TIGR01494: HAD ATPase, P-type, family IC" amino acids 288 to 538 (251 residues), 109 bits, see alignment E=4.2e-35 amino acids 630 to 787 (158 residues), 101 bits, see alignment E=1.1e-32 PF00122: E1-E2_ATPase" amino acids 318 to 496 (179 residues), 150.1 bits, see alignment E=9.8e-48 PF00702: Hydrolase" amino acids 513 to 717 (205 residues), 96.2 bits, see alignment E=7.1e-31

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to rru:Rru_A3324)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RP27 at UniProt or InterPro

Protein Sequence (809 amino acids)

>Rru_A3324 copper-translocating P-type ATPase (NCBI) (Rhodospirillum rubrum S1H)
MDGLSETRPADSADGGTACRHCGLPVPANGPAGAEFCCVGCRGAYGLIRDSGLDQYYQRR
CLDPDTPPPRPEDLGPIDFSAHILRQPTADGGEEAVLHLMVEGIHCAACVWLIETLLGRQ
PGVSQARLNMTTRRLTLRFRPAKGETAADLGANTLLAPVARVGYRLVPYDPALLDQETRR
TEKALVQAMAVAGFASANVMLLSVSVWAGVDMGPRTRDLMHWISALIAVPAVIYAVRPFA
HSAFAALRAGRASMDMPITLAVTLATGVSLWETANGGAHAYFDAAVTLLFFLLIGRFLDH
RARGRARSTAEHLLALGATAVTVLRDDGTLEHRPPRQVTPGATVLVATGERIGVDGTVSQ
GCSDVDTSLLTGETLPEPVHPGSAVFAGTLNLTGPLRLSAGAVGEGTLLAEIVRMMEVAE
QGRARYVAIADRVARAYVPVVHALALASFLGWLTLMGAPWQQALMVAAAVLIVTCPCALA
LAVPVVQVVATGRLLRQGILVKSPTALERLTGVDHVVFDKTGTLTLGRPDLRPADPARAD
AWSAEDLAAAAQLAAASHHPLARALALAAPEAKPAALAREWPGQGMSLPLAEGEARLGRA
VFCGLEDTPAEDGGGPELWFTRPGHAPVRFGFIDRPRPDAAEVVAALRAQGIGVELLSGD
RPAVAAALAARIGLNDWRAGCSPADKVARLAELAAAGKTVLMVGDGLNDAPALAAAHVSL
SPASAVDVTQTAADVVFQGERLTPVIEALGVARRADRLVRQNFVLSFAYNIVTVPLAICG
LVTPLIAAVAMSSSSVVVILNALRLSRRR