Protein Info for Rru_A2935 in Rhodospirillum rubrum S1H

Annotation: PAS/PAC Sensor Hybrid Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 817 transmembrane" amino acids 22 to 43 (22 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 184 to 303 (120 residues), 38.7 bits, see alignment E=4.9e-14 amino acids 306 to 426 (121 residues), 42.1 bits, see alignment E=4.3e-15 PF00989: PAS" amino acids 188 to 290 (103 residues), 25.6 bits, see alignment E=3.7e-09 PF08448: PAS_4" amino acids 194 to 298 (105 residues), 46.7 bits, see alignment E=1.2e-15 amino acids 315 to 421 (107 residues), 51.2 bits, see alignment E=4.8e-17 PF13426: PAS_9" amino acids 200 to 295 (96 residues), 30 bits, see alignment E=1.9e-10 amino acids 321 to 418 (98 residues), 21 bits, see alignment E=1.2e-07 PF13188: PAS_8" amino acids 309 to 363 (55 residues), 16.6 bits, see alignment 2.1e-06 PF00512: HisKA" amino acids 440 to 506 (67 residues), 44 bits, see alignment E=6.4e-15 PF02518: HATPase_c" amino acids 551 to 660 (110 residues), 87.2 bits, see alignment E=3.6e-28 PF00072: Response_reg" amino acids 687 to 798 (112 residues), 40.9 bits, see alignment E=7.3e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2935)

Predicted SEED Role

"probable two-component sensor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RQ63 at UniProt or InterPro

Protein Sequence (817 amino acids)

>Rru_A2935 PAS/PAC Sensor Hybrid Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MINGLADSTGWIAGGVGDGAQIALWVLGGGFLAGAWAWSLRLACRRGERLARARGPHLLD
NLDEAVVVTGGDGRVAYRNRAAARLLAHLAPTAGSEPSLDGFWEKALPLRPARTTDGLVV
ERRLIEGGSLDQGVCLLAIRQSLPPGAFTLDPAEAGNAAGLSGLTLWTLLDVSHWRRLDQ
TVTEREARLSAVLNAIDESIMRIEPDGRIGFINTAGTVILGVARDQVIGQPLAAFSPPAV
AWVRQTRVREVIDGGKAVRFVDRSGDRWREHTFSPIPDGEGRTVAIAACSRDVTAEKRVH
QELCRREQFIRLITDNLPGVVFYVDEADTFKFVNRRVTDWLGKPPTDLLGRPFREGVDPL
LNEATLAGRKAALAGERVDFDSEFVDPDGHTRRFQATFIPHLEGGEVLGYVGLLLDTTKR
VEVEAAVRDALARAEAASTSKSRFLAAASHDLRQPMQALNIYVGLLTRQVREQPRAYELV
QRVGQSVNALGDLLDSLLDVSKLDAGIVTAAPQPFAVNNILERMDTEMRPLFEAKGLRFR
VVKSALMACSDDTLVERILRNLVTNAYRYTQSGGVVLGCRRRGGTVVFQVWDSGIGIPAD
RLDLIFEEFYQVGNQGRDRAQGLGLGLAIVRRLSQLLGHPVAVRSEVGRGTMFEVALPQA
SPEEMEAAVTSWTATGLPAIRDGTLAVVIDDDSAVLDGMALLLEDWGFDVVAAQDMLEAF
EALRGSPKAPAVIIADYRLQAGGTGVAAVQSLRQAFGVTIPGVIVTGDTSPERLREVTAS
GFRLLHKPVRTFDLRAALAEEMGEDALEGIPPQRRGA