Protein Info for Rru_A2897 in Rhodospirillum rubrum S1H

Annotation: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 204 PF08534: Redoxin" amino acids 10 to 152 (143 residues), 44.4 bits, see alignment E=2.3e-15 PF00578: AhpC-TSA" amino acids 10 to 143 (134 residues), 101.9 bits, see alignment E=3.7e-33 PF10417: 1-cysPrx_C" amino acids 164 to 198 (35 residues), 44.6 bits, see alignment 1.7e-15

Best Hits

Swiss-Prot: 52% identical to AHPC_HELPY: Alkyl hydroperoxide reductase C (ahpC) from Helicobacter pylori (strain ATCC 700392 / 26695)

KEGG orthology group: K03386, peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC: 1.11.1.15] (inferred from 100% identity to rru:Rru_A2897)

MetaCyc: 48% identical to peroxiredoxin-1 (Homo sapiens)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Alkyl hydroperoxide reductase subunit C-like protein" in subsystem Oxidative stress or Rubrerythrin or Thioredoxin-disulfide reductase

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RQA1 at UniProt or InterPro

Protein Sequence (204 amino acids)

>Rru_A2897 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen (NCBI) (Rhodospirillum rubrum S1H)
MTESVGTLTGRPVPDFTAPAVLADNSIVEDFCLKDYLAGFYGLIFFYPLDFTFVCPSEIL
AHDHRLPAFAAKEAKVVAISVDSQYSHLAWKKTPIAEGGLGPIGFPMVADISKAIARSFG
VLLETGVALRASFLVDRGGIVRHQTVNDLPLGRNVDETLRMIDALRFHDAHGQVCPAGWK
TGDPGMTASPEGVAAYLSANAERL