Protein Info for Rru_A2895 in Rhodospirillum rubrum S1H

Annotation: Twin-arginine translocation pathway signal (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 310 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details PF01297: ZnuA" amino acids 43 to 304 (262 residues), 267.7 bits, see alignment E=5.9e-84

Best Hits

Swiss-Prot: 62% identical to HPF_HAEI3: Putative metal ABC transporter substrate-binding protein Hpf (hpf) from Haemophilus influenzae (strain NTHi 3655)

KEGG orthology group: K11604, manganese/iron transport system substrate-binding protein (inferred from 100% identity to rru:Rru_A2895)

Predicted SEED Role

"Manganese ABC transporter, periplasmic-binding protein SitA" in subsystem Transport of Manganese

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RQA3 at UniProt or InterPro

Protein Sequence (310 amino acids)

>Rru_A2895 Twin-arginine translocation pathway signal (NCBI) (Rhodospirillum rubrum S1H)
MTTGKGNNGGAWTRRAVLGTAAGVVAALGLGAGRARAARRLKVVTTFTIIADMARNVAGE
AADVVSITKPGAEIHTYQPTPGDLMRARGADLVLWNGLNLELWFEQFFENLGDVPGVVVS
QKVVPIGIGEGPYEGKPNPHAWMSPTAALLYVDTIAEALATHDPQNAALYRDNAASYKRR
IEETVAPLRIALAALPEERRWLVTSEGAFSYLARDFSLRELYLWPINADQQGRPQQVRKV
VDAMRAQAIPAIFSESTISSAPAEQVARETGARYGGVLYVDSLSGPEGPVPSYLDLLRVT
IETILHGLAP