Protein Info for Rru_A2820 in Rhodospirillum rubrum S1H

Annotation: Multi-sensor Hybrid Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 829 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 37 to 56 (20 residues), see Phobius details PF00989: PAS" amino acids 312 to 405 (94 residues), 30.8 bits, see alignment E=9.1e-11 TIGR00229: PAS domain S-box protein" amino acids 312 to 429 (118 residues), 40 bits, see alignment E=1.9e-14 PF13188: PAS_8" amino acids 312 to 360 (49 residues), 29.1 bits, see alignment 2.5e-10 PF08448: PAS_4" amino acids 313 to 424 (112 residues), 44.7 bits, see alignment E=5.1e-15 PF13426: PAS_9" amino acids 317 to 402 (86 residues), 29 bits, see alignment E=3.8e-10 PF00512: HisKA" amino acids 439 to 502 (64 residues), 35 bits, see alignment 4.1e-12 PF02518: HATPase_c" amino acids 546 to 669 (124 residues), 74.7 bits, see alignment E=2.9e-24 PF00072: Response_reg" amino acids 714 to 825 (112 residues), 70 bits, see alignment E=6.9e-23

Best Hits

KEGG orthology group: K13587, two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC: 2.7.13.3] (inferred from 100% identity to rru:Rru_A2820)

Predicted SEED Role

"sensory box histidine kinase/response regulator"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RQH8 at UniProt or InterPro

Protein Sequence (829 amino acids)

>Rru_A2820 Multi-sensor Hybrid Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MSDAVLIREPALWGLGAGLGGALAGGLWSALGELPVAGWVAAIGATIALGSLAALLRRFA
QWGEAAARGGAAAALLDIEDGPRLLIGADGGARYANSQARTLWGGHPPLAHLRQRLHGDM
MAADALGRLEEAARIGLREEVDLPLRDPEGYSGEPEWVRVMVAPGREPGSRLWSCRDVTA
RRAIDEVLLREREELADFLYFLPVGLYSADTDGRLRYANQVFAQWLGRDTDAMVGLDIDA
VMEGPAPEPDGAWEGRLRFLPVDEPAFDAEVRQSTFDDAGQLRTRSVVVRLPAGEAAPTA
GEGGWLRRRPWLFDGAPVGIVLTDPEGAITDCNASFLAMVGLEAADVFDRPLADLAARND
REDLRALVDKVVGGGTAQADIRLVRGEREVAVGVFLSPMTSLSGRPGDPPDGAVAHLIDT
TEQKNLEQQFAQAQKMQAMGQLAGGVAHDFNNLLTAMIGFSDLLLQRHGIGDPSFADIMQ
IKQNANRAANLVRQLLAFSRRQPLRPRLLNVTDALSELSHLLRRLLGERVVLKLAHGREP
VHIRVDPGQFDQVIINLAVNARDAMPGGGQLTISTRREAVETEMNQGTEAVPPGDYVVID
VVDTGTGITRENLGRLFEPFFTTKSEGTAGAGTGLGLSTVYGIVRQTEGFIFVESTLGEG
ATFTIYLPRHEPPVEVAGAGAGGAEGGVGPGDGAPGGGGEEGGEARDLTGKETILLVEDE
DAVRVFGSRALRNKGYTVLEARSGEGALDVLEDGAEIDLLITDMVMPGMDGATLAGRVRE
ARPDLKIILISGYSEDVIRGDIVNQPDTHFLPKPFSLKALAEKVREVLA