Protein Info for Rru_A2725 in Rhodospirillum rubrum S1H

Annotation: Multi-sensor Hybrid Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 834 transmembrane" amino acids 23 to 43 (21 residues), see Phobius details amino acids 50 to 67 (18 residues), see Phobius details PF08448: PAS_4" amino acids 97 to 198 (102 residues), 27.7 bits, see alignment E=1.1e-09 amino acids 343 to 451 (109 residues), 47 bits, see alignment E=1.1e-15 PF13426: PAS_9" amino acids 107 to 197 (91 residues), 27.1 bits, see alignment E=1.7e-09 amino acids 347 to 448 (102 residues), 13.3 bits, see alignment E=3.3e-05 PF12860: PAS_7" amino acids 217 to 326 (110 residues), 54.6 bits, see alignment E=4.6e-18 TIGR00229: PAS domain S-box protein" amino acids 334 to 456 (123 residues), 48 bits, see alignment E=6.8e-17 PF13188: PAS_8" amino acids 338 to 392 (55 residues), 16.8 bits, see alignment 2.1e-06 PF00512: HisKA" amino acids 466 to 529 (64 residues), 35.9 bits, see alignment 2.5e-12 PF02518: HATPase_c" amino acids 573 to 694 (122 residues), 85 bits, see alignment E=2e-27 PF00072: Response_reg" amino acids 716 to 829 (114 residues), 73.8 bits, see alignment E=5.2e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2725)

Predicted SEED Role

"sensory box histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RQS3 at UniProt or InterPro

Protein Sequence (834 amino acids)

>Rru_A2725 Multi-sensor Hybrid Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MPTVDPERLKGDTLDLASIGRDFVIGLSLMVVVMLALAIPTILDRPLPDAVVLAILIPGL
ALVLLLIRRQRTLFKAIDRSGRRLADSEARIRDFAQSSSDWFWETGPTLAYTYASPRLLD
LSGNDPAKIMGQRLSDLCPDPRSDAAERIATRRPFRDLALTVDLGDGYRRHFRLAGRPVL
DDRGVFAGYRGAGVDVTGEIAASARSEALRDLMFDAVDSISEGFVLFDPEGRLVVVNDSY
RYAYPQLADHLVPGITFEELLKVAARGRDLGAEKDLRGWIDERLHRHREGGTNDCKLSDG
RWYRIGEHETRGGGLVKVLMDITEMKTGADRLAQQTALLRTFVDETPVAVAMVDATLRYL
RVSRRWRTEFGLEDRDIIGQRHDVVMPSLPDDWLNDYEQALSGVAIEREEVSIDLGGRTL
WLRRREYPWFLEDGTVGGLMMTAENITERKQAELALLQSQKMEAVGQLAGGIAHEFNNML
TSIGGFARMAQRTPERLERVTMCLAEVVRSADRAAGLTSQLLNFSRRTTEEETLRIPLGA
LLDELRTFLKPVLGERIALDLRCAVESLFVLANRDRLHQALVNLCINARDAMAEGGTVII
ETGHGVPPERLRCRHPHLGAGQHAVLRVIDSGCGIPEEDLPRVFEPFFTTKAQGKGTGLG
LPMVYAMAEQANGAVELDSIVGRGTTVTLYLPLADGAAAAPTIEGPPPLPRGGARILLVE
DEDAVRRFAAMVLEDGGYAVRAATNGREALDIWEAEGGRFDLLISDLVMPELGGLALYDR
LRAHTPLLPAVLMSGYSDEIPSEDAREGEGARRVLAKPVTPDALIAAVEELLTP