Protein Info for Rru_A2508 in Rhodospirillum rubrum S1H
Annotation: 5-aminolevulinic acid synthase (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 60% identical to HEM1_RHIRD: 5-aminolevulinate synthase (hemA) from Rhizobium radiobacter
KEGG orthology group: K00643, 5-aminolevulinate synthase [EC: 2.3.1.37] (inferred from 100% identity to rru:Rru_A2508)MetaCyc: 54% identical to 5-aminolevulinate synthase 2 (Cereibacter sphaeroides)
5-aminolevulinate synthase. [EC: 2.3.1.37]
Predicted SEED Role
"5-aminolevulinate synthase (EC 2.3.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 2.3.1.37)
MetaCyc Pathways
- tetrapyrrole biosynthesis II (from glycine) (4/4 steps found)
- superpathway of heme b biosynthesis from glycine (6/8 steps found)
- 2-amino-3-hydroxycyclopent-2-enone biosynthesis (2/4 steps found)
- superpathway of bacteriochlorophyll a biosynthesis (13/26 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.37
Use Curated BLAST to search for 2.3.1.37
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RRD7 at UniProt or InterPro
Protein Sequence (404 amino acids)
>Rru_A2508 5-aminolevulinic acid synthase (NCBI) (Rhodospirillum rubrum S1H) MDYEGYFAERLHSLKREGRYRVFADLERQVGRFPLARNYRDGEVHEVTIWCSNDYLGMGI HPVVLEATNEALYTCGAGAGGTRNISGTNHYHVLLERELADWYKKDEALLFTSGYVANIT TLMTLGAQIPDLVIFSDSDNHNSMIEGIRHSRAPKEIFRHNDLAHLEELLRKYPKDRAKL IAFESVYSMDGDIAPIAEICDLADKYGAMTFLDEVHAVGMYGETGSGVAERDGVRERLTI IQATMGKAIGCVGGFICASASLIDFVRSFGAGFIFTTSLPPTIAAGALASVRYLKEHNEL RVRHQERAATTKWRLREAGLPVMPSVSHIIPLAVGDASLCKQASDMLLSLHDIYVQPINF PTVPRGTERLRLTATPLHTDEHLDHLVHALSDVWRRLGIGRQAA