Protein Info for Rru_A2406 in Rhodospirillum rubrum S1H

Annotation: Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) and Response Regulator Receiver modulation (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1301 PF08448: PAS_4" amino acids 32 to 154 (123 residues), 33.6 bits, see alignment E=2e-11 amino acids 633 to 743 (111 residues), 29.4 bits, see alignment E=4e-10 PF13426: PAS_9" amino acids 41 to 104 (64 residues), 12.9 bits, see alignment 5.4e-05 amino acids 640 to 739 (100 residues), 43.2 bits, see alignment 2.1e-14 amino acids 761 to 862 (102 residues), 54 bits, see alignment 8.7e-18 PF00512: HisKA" amino acids 215 to 280 (66 residues), 52.5 bits, see alignment 2e-17 PF02518: HATPase_c" amino acids 326 to 436 (111 residues), 101.4 bits, see alignment E=2e-32 PF00072: Response_reg" amino acids 498 to 608 (111 residues), 76.2 bits, see alignment E=1.1e-24 TIGR00229: PAS domain S-box protein" amino acids 623 to 749 (127 residues), 97.8 bits, see alignment E=5.1e-32 amino acids 754 to 870 (117 residues), 57.8 bits, see alignment E=1.3e-19 PF13188: PAS_8" amino acids 627 to 679 (53 residues), 20.4 bits, see alignment (E = 1.9e-07) amino acids 754 to 792 (39 residues), 19.1 bits, see alignment (E = 5e-07) PF00989: PAS" amino acids 628 to 736 (109 residues), 37.9 bits, see alignment E=7.8e-13 amino acids 754 to 860 (107 residues), 49.7 bits, see alignment E=1.7e-16 PF08447: PAS_3" amino acids 651 to 736 (86 residues), 49.1 bits, see alignment 2.9e-16 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 873 to 1032 (160 residues), 111.3 bits, see alignment E=4e-36 PF00990: GGDEF" amino acids 875 to 1030 (156 residues), 143.2 bits, see alignment E=3.2e-45 PF00563: EAL" amino acids 1055 to 1288 (234 residues), 241.9 bits, see alignment E=3.2e-75

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2406)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RRN9 at UniProt or InterPro

Protein Sequence (1301 amino acids)

>Rru_A2406 Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) and Response Regulator Receiver modulation (NCBI) (Rhodospirillum rubrum S1H)
MIPSTTDDARPDLPSDQAERHPEGGADFEAIFRALPGPHLILDADLKIAAVNDAYLQATL
TRRGEILGRGIFEVFPDNPNDPVSEGVRNLRASLLRVLSSRTQDVMSIQKYDVRKPGGGA
GDFELRYWSPINTPVLGADGAVVYIVHYAQDLTEYYASSGQQDFAEGGKDDIVRQMEAEI
FQRSKEVAKSNLKLKEANSELAILYEKTRELDDIKTQFFANVSHELRTPLTLILGPVTSR
QEDPTLAPAEKRVLDMVARNARLLLRHVNDLLDIAKLEAGQMRMQYVRTDVTRLCRFALS
HFDSLAEERAIAFTLEAPAVLWAEIDPEKFRRVLLNLLSNAFKFTPNQGEITVSLIDRGD
DVILRVSDNGPGIPESMWTAVFERFRQVDGGSDRRHGGTGLGLAIVREFVDLHGGEVSIG
QASEGGAAFTVVLPKKAPPDVAVYPEIGDTLAEGPGFYRDIDKGLEGEDRLTDLAPSAAA
SGPASGPAGGVGINAPLVLVVEDNPDMNAFVSEIVAGHYRVISAFDGQEGLEKAHETLPD
LIISDVMMPRMSGETMADTLRQDGLTSDIPIIMLTAKADEAMRARMLRGVVQDYLFKPFS
RLELLARADGLIADHRRKQMVLRESEARFRATFEQAAVGIAHLDPDGHWLRVNHKLCDIV
GYPPDELLTLSFQDITHPDDLRADLRQMEALLAGQIDTYTIEKRYIRKTGESLWINLTVS
LVRDIHNAPAYFISVVENIQSRKEAELQLLLASAVFSNSMEGIFVTDLKGSILAVNPAFS
QITLYEAAEVLGRNARILQSGRQNREFYVALWQDVLTIGSWRGEIWNRRRDGEVFPEWLS
ISSVRNHQGEVTNYIGIFSDLSRIKHSEAKFHHLAHHDPLTGLPNRLLLRSRLDHAIERA
RRTGGRCAVLFLDLDRFKMINDSLGHRAGDTLLRTLGARLTACLGDTGTLARLGGDEFVA
VIEDIDGIPAVGTIALTMLERLREPCRLSEGPEVCIGGSVGISLFPEDGDNPDTLLQHAD
TALGQVKGAGGGAYGFYTRTLTERISARLGLEAGLRHALEQGDFLLHYQPLIALGTGEVE
GVEALVRWAGGDGLLIPPDRFIPLAEDTGLIVPLGEWVLGEACRTMQRWRSQGMPLTVLA
VNLSPRQFRDHAIPALVRRVLEQTGLPASVLELEITESAIMEQGAAAEAQMTGLKHLGVR
LAIDDFGTGYSSLANLRRFPIDKIKIDQSFVRDIPRDAAAEEITATIIAMGRTLKLHVLA
EGVETTDQLDFLSRKQCDSAQGYLFSRPITAAALEKWLALR