Protein Info for Rru_A2322 in Rhodospirillum rubrum S1H

Annotation: CheW protein (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 533 PF01584: CheW" amino acids 34 to 170 (137 residues), 110.4 bits, see alignment E=2.7e-36 amino acids 206 to 352 (147 residues), 105.7 bits, see alignment E=7.9e-35 amino acids 385 to 522 (138 residues), 126.5 bits, see alignment E=3.1e-41

Best Hits

KEGG orthology group: K03408, purine-binding chemotaxis protein CheW (inferred from 100% identity to rru:Rru_A2322)

Predicted SEED Role

"Positive regulator of CheA protein activity (CheW)" in subsystem Bacterial Chemotaxis or Two-component regulatory systems in Campylobacter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RRX3 at UniProt or InterPro

Protein Sequence (533 amino acids)

>Rru_A2322 CheW protein (NCBI) (Rhodospirillum rubrum S1H)
MSEITQAALDSGPDPSQVTGGAAAGALQAGNARQFVIFHVDNDLFAVPLSEVQEIIRMPD
VVCVPLSPAALEGLANLRGSVLPVIRLRHVFGMAPVVHDDATRVVVLDQGRPVGLVVDRV
ANVVSVEADHIEPSGAIGGTVDTDLLTGMIKGDGDRAMVMILDAAKVVAREFQAIGSAPL
APSLGEAGRAEDGRVQAATDGDDESQLVSFEVAGQEYALPIERVQEIVQIPGLITDVPNT
PAHVLGVMTLRNRLLPLVGLREMFGLPTLALTETNKIVVVSLEGGAGGSGRSVGVVMDSV
KEVLRVGHALIDPMPALLARTGNLGEIEAICRLQGGNRLVSILSADAMFNSDEIRAVAAN
ALGEEDAVADEETPGYLGTTDDEEQFVAFRLMNEEYGVPIDSVQEIVRVPEELTRVPKTP
DFIEGVVNLRGVVLPVVDQRRRFGLPGMERNDRQRIMVYTIRGVRTGFIVDSVSEVIRIP
ASLIGPAPVLSDEQQRLIRRVANIEKQKRMILLLDVEQLLDGKELAVVGSVIP