Protein Info for Rru_A2235 in Rhodospirillum rubrum S1H

Annotation: Multi-sensor Signal Transduction Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 865 PF08446: PAS_2" amino acids 17 to 120 (104 residues), 54.4 bits, see alignment E=5e-18 PF01590: GAF" amino acids 149 to 309 (161 residues), 50.6 bits, see alignment E=7.5e-17 PF00360: PHY" amino acids 387 to 500 (114 residues), 67.2 bits, see alignment E=3e-22 PF02518: HATPase_c" amino acids 756 to 862 (107 residues), 91.6 bits, see alignment E=1.1e-29

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2235)

Predicted SEED Role

"Phytochrome, two-component sensor histidine kinase (EC 2.7.3.-)" in subsystem Oxidative stress or Oxygen and light sensor PpaA-PpsR (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RS60 at UniProt or InterPro

Protein Sequence (865 amino acids)

>Rru_A2235 Multi-sensor Signal Transduction Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MCPCGLGAAMDTVHSTCDQEPIHVPGLVQPHGFLVVLDSKSGRIAQVTPGIEAVAGVVAQ
RLIGEPLERVLDPRSAQRCRHRIARPEYPHLIDPFPVRAPGGQSFSAVAHATDQADLVEL
WSDDQETTVEGVFGRLPFAIGHASRAASIEDLCGRAAATVADLTGYERVMVYRFAENWEG
EVIAETLNGPVESYKGQRFPASDIPAQARALYSRNLLRSIPDVHYRPLPLVGRSPDGREL
DMTFCNLRSVSPVHLEYLRNMGVAASFSVSLVVDGRLWGLVACHDRVPRRLSLATMGACQ
VYAETIAQQVLRLDNTRRSRHRSRTGDLIDDISVLLGSGRSLAEALDYTLDDTLALFGAS
RAVISLDGRQWTAEGPLEGAPIQVPPHQRLLLSERLGGRLRLPAELAGSFVGGVLLPLSD
QPDRDFLLLGRPETLRSIEWAGRPEKQPEITPEGGLKIHPRTSFSLWREEVRGRSVAFDP
LDRETAETLSLFLAERLAKQRRQQAVVALEETRQRLRDLAECSSDWLWETTGDGTLALVS
DRINGLGDLRPEELVGRKLVDLVGGGDSGGAPGVDADEIASAFDEGRAFHGLTVSLALLG
RGQWWVRLSGVPQYDGRGQLLGFRGTGTDVTPFKRLQEERVRTQRLEALGRLAGGIAHEI
GNVLQPVLTMAHYASKRLDDRDFLEAALADICEGGARAKDIVRSVLTFARQTPAERRPLV
LAPALARSVAFAAKGHPGLEIITDIPDTAGEIAANSTELSQIVLNLVGNAADAMGGRGRV
FVSLAEAPDLGRMVITIRDEGPGMTLQTQARVFEPFFTTKPEGSGTGMGLAVVHGLVEAW
GGTIGLESAPGSGTKFVISFPINNP