Protein Info for Rru_A2203 in Rhodospirillum rubrum S1H

Annotation: HflK (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 407 transmembrane" amino acids 68 to 89 (22 residues), see Phobius details TIGR01933: HflK protein" amino acids 86 to 366 (281 residues), 273.4 bits, see alignment E=9.8e-86 PF01145: Band_7" amino acids 88 to 280 (193 residues), 85.8 bits, see alignment E=1.9e-28

Best Hits

KEGG orthology group: K04088, membrane protease subunit HflK [EC: 3.4.-.-] (inferred from 100% identity to rru:Rru_A2203)

Predicted SEED Role

"HflK protein" in subsystem Hfl operon

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.-.-

Use Curated BLAST to search for 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RS92 at UniProt or InterPro

Protein Sequence (407 amino acids)

>Rru_A2203 HflK (NCBI) (Rhodospirillum rubrum S1H)
MGWNQQGGGPWGGGGGGGGGPWGSGGRGGNGRGFGGGSGGQPPDLEEMLRRSQERFRKMV
PGGNLGNKGIGLVAILALAVWLLTGFYRVGTDEQGVVMRFGEFTHTTPPGLHYHLPYPIE
AVILPKVTVENRIELGFRGIGENARGRTPSRDVLEESLMLTGDENIIDIDFSVIWVIKDA
GAFLFNLRDPEGTVNRAAESAMREVIGQTPIQVALTEGRQQIEDRTKELLQAMMDEYNAG
ITIRRVQLLKVDPPAQVVDAFNDVQRSRADRERLRNEAEAYRNSVIPEARGQAEQLLQQA
EAYREEIVNRAQGDVARFNSVLEGYRLNRDVTTQRIYLETMEEVLRNVNKVIIDKNGQGV
VPYLPLPEVRARQGGAAAIAPSGLSGAPLRPMSQPIPGLPAAQGGGR