Protein Info for Rru_A2161 in Rhodospirillum rubrum S1H

Annotation: Polyphosphate kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 754 TIGR03705: polyphosphate kinase 1" amino acids 52 to 727 (676 residues), 964.9 bits, see alignment E=1.2e-294 PF13089: PP_kinase_N" amino acids 53 to 157 (105 residues), 131.4 bits, see alignment E=4e-42 PF02503: PP_kinase" amino acids 167 to 345 (179 residues), 197.7 bits, see alignment E=3.6e-62 PF17941: PP_kinase_C_1" amino acids 373 to 538 (166 residues), 245.8 bits, see alignment E=4.4e-77 PF13090: PP_kinase_C" amino acids 545 to 715 (171 residues), 193.1 bits, see alignment E=6.9e-61

Best Hits

Swiss-Prot: 64% identical to PPK1_ACICJ: Polyphosphate kinase (ppk) from Acidiphilium cryptum (strain JF-5)

KEGG orthology group: K00937, polyphosphate kinase [EC: 2.7.4.1] (inferred from 100% identity to rru:Rru_A2161)

Predicted SEED Role

"Polyphosphate kinase (EC 2.7.4.1)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism or Purine conversions (EC 2.7.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RSD4 at UniProt or InterPro

Protein Sequence (754 amino acids)

>Rru_A2161 Polyphosphate kinase (NCBI) (Rhodospirillum rubrum S1H)
MTSAPPPPAVEAIQGVAAQDVAPRTRQGVKPTAAASGDHPEAPVITMDMPDRFINREVSW
LAFNFRVMEEARNTRHPLMERLRFLSISGSNLDEFYMVRVAGLKGQVEAGVNKVSQDGLT
PAQQLTEINQAARQLLEEQQVAWEILHDELAAQGITVVTPGQLSKADRVWLDTYFMGQVF
PVLTPLAIDPAHPFPFIPNLGHALVLQLHRPNDDTSLRALVPLPNHVSRFTRLPSEEGQG
ARYIFLEDMVGLHLDRLFPGFKVSQGGHFRVIRDSEMEIDEEAEDLVMSFESALKRRRRG
HCIRLTLNANMPEELVKLICDEMDVAEEDIFKVRGPIGQADLKQLISDDRPDLQFTPYTA
RFPERIRDFGGDCFAAIRKKDIIVHHPYESFDVVVQFLRQAARDPNVLSIKQTLYRTSNN
SSIVAALVEAAEAGKSVTAMVELKARFDEEANIRWARDLERSGANVVYGFMDLKTHAKIS
LVVRRESGGELRSYVHFGTGNYHPITAKIYTDLSYFTSDEKLCQDAARAFNYMTGYARPG
EMEKLRIAPLGLKEYLLERIQAEEDHARAGRPGTIWAKLNALVDPDVIDALYRASQAGVR
IDLVVRGICCLRPGVAGLSSTIRVKSIVGRFLEHSRIACFGNGKPLPGPDALVYISSADW
MPRNLNRRVESFVPIENPTVKAQVLNQIMVANLNDRAQSWYLTADGVFRRAKASDDAFSA
HTYFMTNPSLSGRGSALNDPEKDIPTLEVSAQRN