Protein Info for Rru_A2160 in Rhodospirillum rubrum S1H

Annotation: Ppx/GppA phosphatase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 509 TIGR03706: exopolyphosphatase" amino acids 20 to 310 (291 residues), 313.3 bits, see alignment E=8.4e-98 PF02541: Ppx-GppA" amino acids 34 to 311 (278 residues), 151.5 bits, see alignment E=3.6e-48 PF21697: Ppx_C" amino acids 320 to 496 (177 residues), 88.7 bits, see alignment E=5.4e-29

Best Hits

KEGG orthology group: K01524, exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC: 3.6.1.11 3.6.1.40] (inferred from 100% identity to rru:Rru_A2160)

Predicted SEED Role

"Exopolyphosphatase (EC 3.6.1.11)" in subsystem Phosphate metabolism (EC 3.6.1.11)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.11, 3.6.1.40

Use Curated BLAST to search for 3.6.1.11 or 3.6.1.40

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RSD5 at UniProt or InterPro

Protein Sequence (509 amino acids)

>Rru_A2160 Ppx/GppA phosphatase (NCBI) (Rhodospirillum rubrum S1H)
MTASAAFPHVPAAPVDLRPLGVVDIGSNSVRLVVYRGLARTPIPLFNEKATCALGKGLGE
TGVLNPEGVALALKAVKRFAHLARRMNVGKLELVATAAVRDAWDGRDFVRALERVSGLPV
SVLSGEQEAKTAALGVLCGLPDADGMVADLGGGSLELVMLDQGRFGDFATMPLGILRLSE
ASDNSRVRAVDIIDEHLAGLPWIPKGRGRTLYAVGGAWRSLARVCIEQMHYPLHVLDNFA
ISRVEALRLIEVLSRLSRKSLESIQGISRKRLPHLPMAAVILERLLEEVRPETLVFSVYG
MREGRFFQNLPPEVRVQDPLISSCSELARSAGRFPEHGEELMAWMAPLLPNESVEQARLR
RAACLISDVFWSEHPDYRADQAFHRVLKLPFMGLNHTDRAGLALTVYYRYTSEGTDDWAM
RAASLLDETRLKRVRIIGHALRLGHTVTGGAPGLLGRSALSAKDGVLTFHVPEDDPIFLP
EVFGKRLEKLARAMGLEPKLALLPPAAQA