Protein Info for Rru_A2109 in Rhodospirillum rubrum S1H

Annotation: ATP-dependent Clp protease ATP-binding subunit ClpA (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 779 TIGR02639: ATP-dependent Clp protease ATP-binding subunit ClpA" amino acids 3 to 741 (739 residues), 1143.7 bits, see alignment E=0 PF02861: Clp_N" amino acids 13 to 61 (49 residues), 48 bits, see alignment 9.4e-16 PF07728: AAA_5" amino acids 218 to 296 (79 residues), 25.3 bits, see alignment E=1.2e-08 amino acids 499 to 615 (117 residues), 50.6 bits, see alignment E=1.8e-16 PF00004: AAA" amino acids 218 to 330 (113 residues), 45.9 bits, see alignment E=6.9e-15 amino acids 499 to 624 (126 residues), 50.6 bits, see alignment E=2.4e-16 PF17871: AAA_lid_9" amino acids 357 to 458 (102 residues), 97.8 bits, see alignment E=2.9e-31 PF07724: AAA_2" amino acids 493 to 654 (162 residues), 198.5 bits, see alignment E=6.9e-62 PF00158: Sigma54_activat" amino acids 497 to 617 (121 residues), 23.6 bits, see alignment E=3.1e-08 PF10431: ClpB_D2-small" amino acids 660 to 740 (81 residues), 95.6 bits, see alignment E=1.2e-30

Best Hits

Swiss-Prot: 72% identical to CLPA_RHOBL: ClpA homolog protein from Rhodobacter blasticus

KEGG orthology group: K03694, ATP-dependent Clp protease ATP-binding subunit ClpA (inferred from 81% identity to mag:amb1123)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpA" in subsystem Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RSI6 at UniProt or InterPro

Protein Sequence (779 amino acids)

>Rru_A2109 ATP-dependent Clp protease ATP-binding subunit ClpA (NCBI) (Rhodospirillum rubrum S1H)
MLSRNLEQTLHRALALASQRRHEYATLEHLLLALVDDQDAVSVLKACSVDVEKLRKQLAE
FVEHELTGLVVAAPEGDPKPTAGFQRVVQRAAIHVQSSGREQVTGANILVALFSERESHA
VYFLQMQDMTRLDAVNYISHGIAKAPGHGQARAPRGADEETKSEETATVKKGREALDAYC
VNLNEKAAEGKIDPLIGRDQEVERTIQILCRRNKNNPLLVGDPGVGKTAIVEGLARRIVH
KEVPEVLHNATIFSLDMGALLAGTRYRGDFEERLKAVVGELEAYEGAVLFIDEIHTVIGA
GATSGGSMDASNLLKPALAQGLLRCVGSTTYKEFRNHFEKDRALVRRFQKIDVNEPSVED
TVKILRGIKSYYEDHHKVRYTNDAVRAAVELSNKYINDRKLPDKAIDVIDEVGAARMLLP
ESRRRKTVTVRDIEEIVAKIARIPPKSVSRDDQAVLKSLERDLKTMVFGQDQAIEALASA
IKLARAGLREPTKPIGNYLFSGPTGVGKTEVARQLARILGIELVRFDMSEYMERHSVSRL
IGAPPGYVGFDQGGLLTDAVDQQPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKH
VDFRNVILIMTTNAGAQMLAKNAMGFGRETRSGDDTEEIERSFSPEFRNRLDAIIPFANL
AAETVGMVVDKFVMELEAQLADRNVTIELTDKARSWLAEKGYDRRMGARPLARIIQETIK
KPLAEELLFGKLTKGGRVKVGVKDGKPDFAFFDLPPKDLLEKEGERGDNDESPTEEVAD