Protein Info for Rru_A1908 in Rhodospirillum rubrum S1H

Annotation: Putative diguanylate cyclase (GGDEF domain) with PAS/PAC sensor and Response Regulator Receiver modulation (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 519 TIGR00229: PAS domain S-box protein" amino acids 225 to 346 (122 residues), 39 bits, see alignment E=8e-14 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 348 to 508 (161 residues), 155 bits, see alignment E=1.5e-49 PF00990: GGDEF" amino acids 351 to 504 (154 residues), 136.7 bits, see alignment E=9.8e-44

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A1908)

Predicted SEED Role

"diguanylate cyclase (GGDEF domain) with PAS/PAC sensor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RT37 at UniProt or InterPro

Protein Sequence (519 amino acids)

>Rru_A1908 Putative diguanylate cyclase (GGDEF domain) with PAS/PAC sensor and Response Regulator Receiver modulation (NCBI) (Rhodospirillum rubrum S1H)
MGRKQLNHIKCRENCSLVAKAGFRHRRVIIQGIQSAMVQDSDEILFVEEEDPVAGSLPSD
VSPWKVLVADDDPEVFTVTRLVLSGFVFAGRGVSLLYAGSAAEATEILRQQSDIAVALLD
VVMETEDAGLKLVKVIRDDLGNSHLRIVLRTGQPGQAPEHDVVMRYDINDYRSKTELTDT
KLITTLVSSLRSYQQIEALERSRAELREARDTLEIRVAERTRDLRESEARLRSILDASVF
PILVLSEEGDRVRFLNDHAGEALGWALLENTTSTLPDLWENPVDGARLLARTVQRGRVLD
CEFRLRGAGGEPFWALVSTIAMSYDGQPAVLLSFNDITVHKQREEAWQRLALTDPLTGLG
NRRLLFDRGILEVARARRGCWPLSGLMIDLDHFKRINDTQGHAAGDAILRTLADTLRESL
REIDVIARVGGEEFAILLPDTSLTAAHEVGERLRLSCQIPQPVGGPVTISVGISTLHPED
RGLGDMLSRADDALYRAKRNGRDRVEIADDSEDNQDVSP