Protein Info for Rru_A1894 in Rhodospirillum rubrum S1H

Annotation: heavy metal translocating P-type ATPase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 754 transmembrane" amino acids 108 to 126 (19 residues), see Phobius details amino acids 138 to 156 (19 residues), see Phobius details amino acids 168 to 190 (23 residues), see Phobius details amino acids 196 to 215 (20 residues), see Phobius details amino acids 350 to 372 (23 residues), see Phobius details amino acids 378 to 406 (29 residues), see Phobius details amino acids 698 to 715 (18 residues), see Phobius details amino acids 721 to 741 (21 residues), see Phobius details PF00403: HMA" amino acids 25 to 84 (60 residues), 45.4 bits, see alignment 1.3e-15 TIGR01511: copper-translocating P-type ATPase" amino acids 151 to 742 (592 residues), 547.1 bits, see alignment E=1.1e-167 TIGR01525: heavy metal translocating P-type ATPase" amino acids 170 to 740 (571 residues), 597.7 bits, see alignment E=5.3e-183 TIGR01494: HAD ATPase, P-type, family IC" amino acids 206 to 466 (261 residues), 150.4 bits, see alignment E=1.2e-47 amino acids 541 to 714 (174 residues), 137.2 bits, see alignment E=1.1e-43 PF00122: E1-E2_ATPase" amino acids 235 to 334 (100 residues), 100.4 bits, see alignment E=6.9e-33 PF00702: Hydrolase" amino acids 431 to 653 (223 residues), 124.6 bits, see alignment E=1e-39

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to rru:Rru_A1894)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RT51 at UniProt or InterPro

Protein Sequence (754 amino acids)

>Rru_A1894 heavy metal translocating P-type ATPase (NCBI) (Rhodospirillum rubrum S1H)
MSGKAAVLSPPAPPTSNEGGDVVDLAISGMTCAACSARLEKVLGKVPGVSAVSVNLGTDR
ARIHIEGGDRRAPDLVAAVNRAGFGAEPLSQSAPPPAAVPAEDRGDRLIFAMAALLTLPL
VWDMIAHVSGLPGHVPPLWQWILATPVQFIAGARFYKGAWRALKGRAGNMDSLVVLGSTA
AYGLSAWRVATGTTHHGLYFEGAAVVITLVMLGKALEGRAKRSAASAIRALMTLRPALAH
LERDGVVSDVAVERLVVGDIVVVRPGEGVPVDGTVIEGGAAIDESLLTGESLPVTRGPGD
RVIGGSIDTDGLIRLRVGATGKDATLARIIALVENAQASKAPVQVMVDKVAAVFVPAVVL
LALGAFTGWALLGETMETAVAAAISVLVVACPCALGLATPTAVMVGTGVAARRGILIRDA
GALEQAHRVSVLAFDKTGTLTQGRPALDAVIIAPGADGLDENTLLALAAAVQGGSAHPLA
RAMREAAGDRGLDLSAISDFRSLPGLGVEARVAGRALILGSRRLLDAKGIERASLESRAG
ALEEAGASVVWVAEGEATGGRLLGVIALADPPREGAALAVSRLKALGVRPVMLTGDAGRV
AHAIAARLGIDDVRAEVLPEGKAAVVEALRQGGAVVAMVGDGVNDAPALAAADVGIAMGT
GTDVAMETAGITLMRGDPGLLPEALALSRATHRKIRQNLFWAFLYNVIALPLAASGRLDP
MLAGAAMALSSVSVVASSLWLRRWMPPSGDRFRA