Protein Info for Rru_A1436 in Rhodospirillum rubrum S1H

Annotation: Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 617 signal peptide" amino acids 1 to 44 (44 residues), see Phobius details transmembrane" amino acids 312 to 333 (22 residues), see Phobius details PF00512: HisKA" amino acids 400 to 464 (65 residues), 33.4 bits, see alignment E=3.8e-12 PF02518: HATPase_c" amino acids 511 to 615 (105 residues), 75.1 bits, see alignment E=6e-25

Best Hits

KEGG orthology group: K10125, two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC: 2.7.13.3] (inferred from 100% identity to rru:Rru_A1436)

Predicted SEED Role

"C4-dicarboxylate transport sensor protein dctB (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RUF8 at UniProt or InterPro

Protein Sequence (617 amino acids)

>Rru_A1436 Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MTTQALSPGRASRWPRLGWRHWAALALALLVLFGLDRLSQAGAQSWTLSHARDAARAAWT
SRAAVLQSEIEKQRSLPLVLASDPDLGRALESRDPAHIAALNEKFETLAAGTRAGVIYLL
DLGGVAIAASNWRAADSFVGSDYGFRPYFRLALDERATEHFALGTVSHRPGLYIARRIDG
ARGPLGVLVVKVEFETIEAQWQGFAEPTFVTDAQGVVIITSLPSWRFLAEIPKSAEESAR
IRASLPFEKAPLTPLPIRRADAVGTVVVALPTSRADRANERPFVLEAGPQPATAWTLHVL
APARVPAAVAAAARTFALMLSTGVICGSGLWYARSLRRARERGRQRAARIELEERVSERT
AELRSANDRLLTEIDERRRAEAALQDLQDELVQARKLAVLGQIAASVAHEINQPVAAIRT
FADNARIFLARAQPEGADHNLQTIATLTERIGAITGELRAFARKSPSRVEPVSLRSAIDG
ALLLVGHRLRQQAVTLGVDIAEGDLTVAAERVRLEQVLVNLLQNAVEALAGRRDGTIRIA
AIADRARVTVTVCDNGPGLSPDVVGSLFMPFTTTKPTGLGLGLVIAKDIIAEFGGSFTGE
NAASGGARFTITLARPQ