Protein Info for Rru_A1414 in Rhodospirillum rubrum S1H

Annotation: regulatory protein GntR (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 258 PF00392: GntR" amino acids 12 to 71 (60 residues), 45.5 bits, see alignment E=5e-16 PF07729: FCD" amino acids 100 to 225 (126 residues), 83.6 bits, see alignment E=1.6e-27

Best Hits

Swiss-Prot: 37% identical to PDHR_SALTY: Pyruvate dehydrogenase complex repressor (pdhR) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K05799, GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex (inferred from 100% identity to rru:Rru_A1414)

Predicted SEED Role

"Lactate-responsive regulator LldR in Enterobacteria, GntR family" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RUI0 at UniProt or InterPro

Protein Sequence (258 amino acids)

>Rru_A1414 regulatory protein GntR (NCBI) (Rhodospirillum rubrum S1H)
MIMSEPIRATRLAETIADHLERLIAEGALRPGERLLPERELALKLNVSRPSLRDGLAAME
RRGLIVTDRQGSRVAEFLRPLTEPLELLIQNNTQATFDYLEFRFVVEGAAAEMAAKRATD
LDRAAIRAILDRMAAVHGDDDSAAEAEADADLHSATYEATYNVMILHIMRGFSQLLRRDV
FYNRERLYARPGVRDLLLGHHQAIGEAIIAGDGPAARRAAEEHITVTRETLEEIRDADAR
LAMSLRRIGRRDLVAPER