Protein Info for Rru_A1406 in Rhodospirillum rubrum S1H

Annotation: Two component CheB methylesterase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 363 PF00072: Response_reg" amino acids 7 to 109 (103 residues), 81.1 bits, see alignment E=6.9e-27 PF01339: CheB_methylest" amino acids 179 to 357 (179 residues), 231.6 bits, see alignment E=5.2e-73

Best Hits

Swiss-Prot: 100% identical to CHEB2_RHORT: Protein-glutamate methylesterase/protein-glutamine glutaminase 2 (cheB2) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K03412, two-component system, chemotaxis family, response regulator CheB [EC: 3.1.1.61] (inferred from 100% identity to rru:Rru_A1406)

Predicted SEED Role

"Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61)" in subsystem Bacterial Chemotaxis (EC 3.1.1.61)

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.61

Use Curated BLAST to search for 3.1.1.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RUI8 at UniProt or InterPro

Protein Sequence (363 amino acids)

>Rru_A1406 Two component CheB methylesterase (NCBI) (Rhodospirillum rubrum S1H)
MPRKIRVLIVDDSASVRQTMTEILESDPGIEVIGTAPDPYVAARRIQQEVPDVITLDVEM
PRMDGITFLRKIMAQRPIPVVVCSSLTETDSETASQAWEAGAVEIILKPRVGTAQFLLES
KIHICDVVKAAAGARLRSMPAAGRANRPRVPEKKLTADAVLPPPVAGRNAMARTTESVIC
IGASTGGTESLREVLEALPAASPAIVIVQHMPEKFTEAFARRLDSLCDMEVKEAVDGDTV
MRGRVLIAPGNHHMLLQRSGARYYVSVKDGPLVSRHRPSVDVLFRSAASHAGSNAVGIIM
TGMGDDGARGLLEMRKAGAYTIAQDEATSVVFGMPKEAIALGAADKILPLEMLAMEILRA
GNR