Protein Info for Rru_A1379 in Rhodospirillum rubrum S1H

Annotation: Acetate kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00016: acetate kinase
  • amino acids 3 to 392 (390 residues), 459.7 bits, E=3.8e-142
• PF00871: Acetate_kinase
  • amino acids 5 to 387 (383 residues), 480.7 bits, E=1.4e-148

Best Hits

Swiss-Prot: 52% identical to ACKA_CHRVO: Acetate kinase (ackA) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)

KEGG orthology group: K00925, acetate kinase [EC: 2.7.2.1] (inferred from 100% identity to rru:Rru_A1379)

MetaCyc: 55% identical to propionate kinase (Escherichia coli K-12 substr. MG1655)
Acetate kinase. [EC: 2.7.2.1, 2.7.2.14, 2.7.2.15, 2.7.2.7]

Predicted SEED Role

"Acetate kinase (EC 2.7.2.1)" in subsystem Ethanolamine utilization or Fermentations: Lactate or Fermentations: Mixed acid or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Threonine anaerobic catabolism gene cluster (EC 2.7.2.1)

MetaCyc Pathways

• Bifidobacterium shunt (13/15 steps found)
• L-threonine degradation I (6/6 steps found)
• pyruvate fermentation to acetate and (S)-lactate I (4/4 steps found)
• pyruvate fermentation to acetate and lactate II (4/4 steps found)
• acetyl-CoA fermentation to butanoate (6/7 steps found)
• pyruvate fermentation to acetate I (3/3 steps found)
• pyruvate fermentation to acetate II (3/3 steps found)
• pyruvate fermentation to acetate IV (3/3 steps found)
• pyruvate fermentation to acetate VII (3/3 steps found)
• superpathway of acetate utilization and formation (3/3 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (10/13 steps found)
• acetate and ATP formation from acetyl-CoA I (2/2 steps found)
• superpathway of Clostridium acetobutylicum acidogenic fermentation (7/9 steps found)
• ethanolamine utilization (4/5 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (14/19 steps found)
• superpathway of L-threonine metabolism (13/18 steps found)
• pyruvate fermentation to butanoate (5/7 steps found)
• glycine degradation (reductive Stickland reaction) (1/2 steps found)
• reductive glycine pathway of autotrophic CO₂ fixation (6/9 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (6/9 steps found)
• mixed acid fermentation (11/16 steps found)
• (S)-propane-1,2-diol degradation (3/5 steps found)
• acetylene degradation (anaerobic) (3/5 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (11/17 steps found)
• methanogenesis from acetate (3/6 steps found)
• L-lysine fermentation to acetate and butanoate (5/10 steps found)
• superpathway of L-alanine fermentation (Stickland reaction) (4/9 steps found)
• L-glutamate degradation VII (to butanoate) (6/12 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (3/8 steps found)
• superpathway of N-acetylneuraminate degradation (13/22 steps found)
• gallate degradation III (anaerobic) (5/11 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)
• purine nucleobases degradation II (anaerobic) (12/24 steps found)
• superpathway of methanogenesis (3/21 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Propanoate metabolism
• Pyruvate metabolism
• Taurine and hypotaurine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.2.1

Use Curated BLAST to search for 2.7.2.1 or 2.7.2.14 or 2.7.2.15 or 2.7.2.7

Sequence Analysis Tools

See Q2RUL5 at UniProt or InterPro

Protein Sequence (408 amino acids)

>Rru_A1379 Acetate kinase (NCBI) (Rhodospirillum rubrum S1H)
MLSPLILVINCGSSSLKFALFPLEGRTPVLVGLAECLGQAEASIRIDHAGTRDKRAIANA
GHQQALDCLLGRLGEMGLLEPISAVGHRVVHGGERFTGSAPITPEVLADIEACAQLAPLH
NRANLIGIFAAMKALPDTPQVAVFDTAFHQTMPPEAYLYALPRLYHSRLGVRRYGFHGTS
HRFVAAEAVKLLGLDPDHHGLIIAHLGNGASATAVLNGRSVDTTMGMTPLEGLVMGTRSG
DVDFGVLAHIARHEGLDIDGLEALLNKTSGLLGLSGLSGDCRALQEAASQGHAGATEALG
VFVHRLVRHIGALAMSLPRLDALIFTGGIGENSALIRGRTLDHLGLLGFELDSAANDTMP
RGESGVISRGAGPKAAVLPTNEEWMIAHDTAAIAGLLSNSAQNERLAS