Protein Info for Rru_A1287 in Rhodospirillum rubrum S1H

Annotation: Trimethylamine-N-oxide reductase (cytochrome c) (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 823 signal peptide" amino acids 1 to 44 (44 residues), see Phobius details TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 14 to 41 (28 residues), 18.3 bits, see alignment (E = 2.3e-07) PF18364: Molybdopterin_N" amino acids 51 to 91 (41 residues), 68.3 bits, see alignment 6.6e-23 TIGR00509: molybdopterin guanine dinucleotide-containing S/N-oxide reductases" amino acids 52 to 822 (771 residues), 1202.4 bits, see alignment E=0 PF00384: Molybdopterin" amino acids 95 to 562 (468 residues), 268.7 bits, see alignment E=1.2e-83 PF01568: Molydop_binding" amino acids 680 to 798 (119 residues), 82.5 bits, see alignment E=3.4e-27

Best Hits

Swiss-Prot: 70% identical to DSTOR_RHOSH: Dimethyl sulfoxide/trimethylamine N-oxide reductase (dmsA) from Rhodobacter sphaeroides

KEGG orthology group: K07812, trimethylamine-N-oxide reductase (cytochrome c) 2 [EC: 1.7.2.3] (inferred from 100% identity to rru:Rru_A1287)

Predicted SEED Role

"Trimethylamine-N-oxide reductase (EC 1.6.6.9)" in subsystem trimethylamine N-oxide (TMAO) reductase (EC 1.6.6.9)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.6.6.9 or 1.7.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RUV7 at UniProt or InterPro

Protein Sequence (823 amino acids)

>Rru_A1287 Trimethylamine-N-oxide reductase (cytochrome c) (NCBI) (Rhodospirillum rubrum S1H)
MSKMSPPTAFAAQTRRTFLKASAAAGALGLVAPSLLSAGVARAAEDGEVLTGSHWGAFRA
TVKGGKMTAIKPWEKDPHPSHQLTGVMDSIYSPTRIKYPMVRRAFLEKGPGASPETRGAG
DFVRVTWDQALDLVAKELTRVRKDHGPTSIFAGSYGWMSPGKLHNCRSLVRRLLNQTGGF
VSSSGDYSTGASQVIMPHVMGTLEVYEQPTVWPVVVEHSDLVVFWGADPMTTNQIGWLIP
DHGAYVGLKALKESGKKVICIDPVRTETCDYLGAEWIAPKPQTDMAMMLGVAHTLYTEKL
HDQSFLDDYTFGFDRFLPYLTGESDKTPKSAEWASAICGIPAEVIKDLARRIVKGRTMLA
SGWSMQRQHHGEQIHWMLVTLASMVGQIGLPGGGFGLSYHYANGGSPSATGPVLPAISDG
SAAVKGAAWLAAGGAASIPVARVVDMLMNPGKEFDFNGTKAIYPDTKLIYWTGGNPFAHH
QNRNRMVEAFRKVETFIVHDFQWTATARHADIVLPATTSYERNDIEQIGDYALSSVLAMK
KVVEPVFEARSDFDILAAVAERLGTRDAFTEGKDEMGWIKEFYDNALGQAKAKGVTMPDF
ETFWKGEGVVSFPISDEAKAFVRYSAFREDPLLEPLGTPTGKIEIYSKNIEKMGYDDCPA
HPTWMEPVERLDGPGAKFPLHITTSHPKSRLHSQLCGTKLRDSYTVAGREPCLINEADAK
ARGISNGDVVRVFNDRGQILAGAVVTNAIRPGVIRVNEGGWYDPTEPTKPGSLCKYGDVN
VLTVDIGTSKLAQGNCGHTAIGDVEKYAEAAPAVTVFAAPKNA