Protein Info for Rru_A1098 in Rhodospirillum rubrum S1H

Annotation: Peptidase M41, FtsH (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 640 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details amino acids 103 to 123 (21 residues), see Phobius details PF06480: FtsH_ext" amino acids 7 to 95 (89 residues), 50.2 bits, see alignment E=7.8e-17 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 103 to 596 (494 residues), 793.2 bits, see alignment E=5e-243 PF07728: AAA_5" amino acids 190 to 312 (123 residues), 27.5 bits, see alignment E=8.5e-10 PF00004: AAA" amino acids 191 to 323 (133 residues), 157.7 bits, see alignment E=6.4e-50 PF17862: AAA_lid_3" amino acids 346 to 390 (45 residues), 53.4 bits, see alignment 4.2e-18 PF01434: Peptidase_M41" amino acids 404 to 595 (192 residues), 239.3 bits, see alignment E=9.2e-75

Best Hits

Swiss-Prot: 69% identical to FTSH_ZYMMN: ATP-dependent zinc metalloprotease FtsH (ftsH) from Zymomonas mobilis subsp. mobilis (strain NCIMB 11163 / B70)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to rru:Rru_A1098)

MetaCyc: 64% identical to ATP-dependent zinc metalloprotease FtsH (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RVE6 at UniProt or InterPro

Protein Sequence (640 amino acids)

>Rru_A1098 Peptidase M41, FtsH (NCBI) (Rhodospirillum rubrum S1H)
MNLSRNLLLWIIIAVLLVVLFNLFQTSAPRGPQTTVPYSDFLSSVDAREVRDVVIKGDSI
SGHTTDGRAFTTYAPRDADMVSHLRDSGVQISAVPAEDNVPTFWSILISWFPFLLLIGVW
IFFMRQMQSGGGKAMGFGKSRAKLLTEKTGRVTFDDVAGIDEAKQELEEVVEFLRDPQKF
QRLGGKIPKGVLLVGPPGTGKTLLARAIAGEANVPFFTISGSDFVEMFVGVGASRVRDMF
EQGKKNAPCLIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEANEGVILIAAT
NRPDVLDPALLRPGRFDRQVTVSNPDIMGREKILKVHMRKTPLGPDVDAKVIARGTPGFS
GADLSNLVNEAALLAARKGKRVVTMAEFEEAKDKVLMGAERRSMVMTEDEKEKTAYHEAG
HALIAIHQEGHDPLHKVTIIPRGRALGVTMSLPERDRYGYSLKELKARIAMAFGGRVAEE
MIYGTENVTTGASNDIMQATDLARRMVTEFGFSEKLGPLRYTDNQEEVFLGHSVTQHKNL
SDETARMIDEEVRRFVEQGEARAREILGKYKDELEIITRGLLEYETLSGDEVNKLLRGED
LNRAEQPAPPRDRSGRRASVPTSGPAAGGVGGDPEPQPGA