Protein Info for Rru_A0972 in Rhodospirillum rubrum S1H
Annotation: Prephenate dehydrogenase (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00210, prephenate dehydrogenase [EC: 1.3.1.12] (inferred from 100% identity to rru:Rru_A0972)Predicted SEED Role
"Prephenate and/or arogenate dehydrogenase (unknown specificity) (EC 1.3.1.12)(EC 1.3.1.43)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.12, EC 1.3.1.43)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tyrosine biosynthesis (10/10 steps found)
- L-tyrosine biosynthesis I (3/3 steps found)
- L-tyrosine biosynthesis III (2/4 steps found)
- 4-hydroxy-3-prenylbenzoate biosynthesis (1/4 steps found)
- superpathway of chorismate metabolism (37/59 steps found)
- superpathway of novobiocin biosynthesis (4/19 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.3.1.12, 1.3.1.43
Use Curated BLAST to search for 1.3.1.12 or 1.3.1.43
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RVS2 at UniProt or InterPro
Protein Sequence (317 amino acids)
>Rru_A0972 Prephenate dehydrogenase (NCBI) (Rhodospirillum rubrum S1H) MGQTAFLADHPRFHRPAPAGTPLAVRRPSGLAAKPTLGLIGLGAFGAFCVPHLSRFFHIL GHDPARDGAARALALGVLPATLAEAAAASIVIPAVPVAVLAEVTAAIAPHLRPGALVVDV CSLKVEPMAVLERILPAGVIVVGTHPLFGPASGAKGIKDLRVAVCPGHGPAGAKAEDRVA AFLARRLGLAVHRVSAVEHDRQMAYVQGLTHLLARIVTKLDVPEMSLATGTFDHLMRMVH TVDRDSEALFRTITEANPFVGDLKARLGAITAEVCAPRDGAELQPPALSSALAASGVSTS ISTDAPSARASIATSQV