Protein Info for Rru_A0886 in Rhodospirillum rubrum S1H

Annotation: Hydrophobe/amphiphile efflux-1 HAE1 (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1052 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 341 to 361 (21 residues), see Phobius details amino acids 368 to 389 (22 residues), see Phobius details amino acids 395 to 418 (24 residues), see Phobius details amino acids 439 to 461 (23 residues), see Phobius details amino acids 471 to 497 (27 residues), see Phobius details amino acids 546 to 566 (21 residues), see Phobius details amino acids 875 to 896 (22 residues), see Phobius details amino acids 903 to 926 (24 residues), see Phobius details amino acids 932 to 954 (23 residues), see Phobius details amino acids 981 to 1001 (21 residues), see Phobius details amino acids 1009 to 1034 (26 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1043 (1041 residues), 1145.5 bits, see alignment E=0 PF00873: ACR_tran" amino acids 4 to 1035 (1032 residues), 1184.6 bits, see alignment E=0 PF03176: MMPL" amino acids 300 to 499 (200 residues), 41.2 bits, see alignment E=1.6e-14 PF02355: SecD_SecF_C" amino acids 342 to 497 (156 residues), 23.8 bits, see alignment E=4.1e-09

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 71% identity to avi:Avi_5484)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RW08 at UniProt or InterPro

Protein Sequence (1052 amino acids)

>Rru_A0886 Hydrophobe/amphiphile efflux-1 HAE1 (NCBI) (Rhodospirillum rubrum S1H)
MSLSKFFIDRPIFAGVISTVILLAGLISMVLLPISEYPEVVPPSVIVKAQFPGANPKVIA
QTVATPLEEQINGVEDMLYMSSQAASDGTMTLTISFKLGTDPDLATQLVQNRVNQALTRL
PEVTRQLGVTTVKSSPDLTMVVHLTSPNERYDMLYLRNYALLNVKDQLAKIQGIGSVQLF
GSGDYAMRIWLDPQKVAERGMTATEVIAAIRRQNVQVAAGVIGGPPYGTGVAVQVPVNAQ
GRLTDADEFREIIIKRDGGVVTRLKDVARIDLDAAQYGLRSLLDNKPAVAIPVFQAPGSN
AIEISNQVRATMAELKKSFPEGLDYAIAYDPTVFVRGSIEAVVHTLLEAVALVVIVVILF
LQTWRASIIPLLAVPISIIGTFAVMHLFGFSINALSLFGLVLAIGIVVDDAIVVVENVER
NIENGLSPRDATLKAMREVTGPIIAIALVLCAVFVPIAFISGLTGQFYRQFALTIAFSTV
ISAFNSLTLSPALAVTLLRGEGAPKDALTRGMDRVLGPFFRGFNRVFHASSHGYGRGVGG
ILGRKSLAMLVYVGLLGATYLGFAQVPPGFVPSQDKQYLVGFAQLPEGATLDRTESVIRA
MSDIALRDPGVESAIAFPGLSINGFINSPSAGVVFVTLKPFEQRESAELSGFAISQRLQQ
RYAGVSEAFIAIFPPPPVQGLGTIGGFKLQVEDRTDQGYEALDQTMKAVLAKAATTPELA
GVFSSYKIGTPELYADLDRTKAAQLGVDVQEVFDTMQIYLGSLYVNDFNKFGRTYQVIAQ
ADGAFRSKPDDILRLQTRNFDGRMVPLGAVVTLSDTSGPDSAMRYNAFRSADLNGGPAPG
YSTGQAQGAMTKLLAETLPKGMDFEWTELTYQQILAGNTTMMVFPLCVLLVFLVLAAQYE
SLFLPLAIILIVPLCLLSAITGVWLTGGDNNMFTQIGLFVLIGLACKNAILIVEFARELE
IDGQDTVPAAIEAARLRLRPILMTSIAFIMGVVPLVISSGAGAEMRHAMGIAVFSGMLGV
TVFGLFLTPVFYVLMRSLEKRVTGTQKVHHHV