Protein Info for Rru_A0749 in Rhodospirillum rubrum S1H

Annotation: Glutamyl-tRNA reductase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 441 transmembrane" amino acids 255 to 269 (15 residues), see Phobius details TIGR01035: glutamyl-tRNA reductase" amino acids 15 to 407 (393 residues), 259 bits, see alignment E=4.1e-81 PF05201: GlutR_N" amino acids 17 to 166 (150 residues), 127.3 bits, see alignment E=6.7e-41 PF01488: Shikimate_DH" amino acids 182 to 316 (135 residues), 69.6 bits, see alignment E=4.6e-23 PF00745: GlutR_dimer" amino acids 330 to 423 (94 residues), 37.9 bits, see alignment E=2.8e-13

Best Hits

Swiss-Prot: 100% identical to HEM1_RHORT: Glutamyl-tRNA reductase (hemA) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K02492, glutamyl-tRNA reductase [EC: 1.2.1.70] (inferred from 100% identity to rru:Rru_A0749)

Predicted SEED Role

"Glutamyl-tRNA reductase (EC 1.2.1.70)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 1.2.1.70)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.70

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RWE2 at UniProt or InterPro

Protein Sequence (441 amino acids)

>Rru_A0749 Glutamyl-tRNA reductase (NCBI) (Rhodospirillum rubrum S1H)
MAQERTAGCGVDGYVMVGVNHQTTPMALRDRLVLDDPALAALLVRLRARGVTEALALSTC
DRVEIFGHGGDPRALRALLLAELCAVGPIEPAALAGQMVDLRGLAVVAHMFRITSALESQ
VLGEPHILGQVKAAHRIARDAGTVGSATEALMQAAYAIAKRVRSETRISEGPVSLAAVAA
QIARDLHGDLGETCLLLLGTQEMGELIAEQLQMAGVGRLVVCAPRRPRAEAVAARLGASV
GDHGALLDLLPNADIVVVGVGGGLLALGEEAMRRTLKRRRNRPVFIVDAGVPGNVEPSVQ
RLEAAFLYDLADLEAVAEEGRAARDQASREAHALVADAVAAFERHRAERAAVPAIAALRA
HFEGERLRALAEAPDDAEKATRLLVGRLLHGPSEALRDLAAGSADKEFMTVRAEMLLRRL
FDLPTSIAETGATDREDGSKG