Protein Info for Rru_A0697 in Rhodospirillum rubrum S1H

Annotation: Multi antimicrobial extrusion protein MatE (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 signal peptide" amino acids 1 to 39 (39 residues), see Phobius details transmembrane" amino acids 60 to 85 (26 residues), see Phobius details amino acids 106 to 129 (24 residues), see Phobius details amino acids 142 to 163 (22 residues), see Phobius details amino acids 172 to 194 (23 residues), see Phobius details amino acids 204 to 225 (22 residues), see Phobius details amino acids 248 to 271 (24 residues), see Phobius details amino acids 284 to 308 (25 residues), see Phobius details amino acids 329 to 349 (21 residues), see Phobius details amino acids 367 to 385 (19 residues), see Phobius details amino acids 406 to 428 (23 residues), see Phobius details amino acids 434 to 452 (19 residues), see Phobius details PF01554: MatE" amino acids 29 to 189 (161 residues), 81.2 bits, see alignment E=3.5e-27 amino acids 257 to 422 (166 residues), 95.1 bits, see alignment E=1.8e-31 TIGR00797: MATE efflux family protein" amino acids 29 to 436 (408 residues), 227.1 bits, see alignment E=1.8e-71

Best Hits

Swiss-Prot: 60% identical to NORM_BRUME: Probable multidrug resistance protein NorM (norM) from Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 100% identity to rru:Rru_A0697)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RWJ4 at UniProt or InterPro

Protein Sequence (468 amino acids)

>Rru_A0697 Multi antimicrobial extrusion protein MatE (NCBI) (Rhodospirillum rubrum S1H)
MISSSVSLPRSGHGAWRTELGATLSLAWPLILTNLAQAALTTTDLLLIGSLGSRSLAAAA
MAAGLFQALMLFGLGLVSATLPLLATALGRNRHSVRDVRRTVRQGLWSAGLISLPLWLIL
WHTEAVLIAFGQEPALAAEAAGFMHTLQWGLLPFLGYIVLRAFLSALERPMWPLLVAGLA
IGFNALAAWALIFGHLGLPALGLPGAGVSSSLSSLFMVAGLALVITRQRRLKRYRLFGRF
WRPDWPRLVTLWRLGLPMAISFAFEVSIFQASMMMMGILGADALAAHTIALQIATLTFMV
PLGLGQAATVRVGRALGAGTIPALRRAGWVAYGAGVAFMGGAALMMLSVPRLLIGAFLDA
DLAENAPVIDLAVVLMALAALFQIADGAQAVCNGMLRGLHDTKVPMLLAALGYWGLGLPL
GALLAFPLGVGAPGVWIGLAGGLSVVAVLMTRRWIRLVAALERASVTA